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Literature summary extracted from

  • Apuya, N.R.; Park, J.H.; Zhang, L.; Ahyow, M.; Davidow, P.; Van Fleet, J.; Rarang, J.C.; Hippley, M.; Johnson, T.W.; Yoo, H.D.; Trieu, A.; Krueger, S.; Wu, C.Y.; Lu, Y.P.; Flavell, R.B.; Bobzin, S.C.
    Enhancement of alkaloid production in opium and California poppy by transactivation using heterologous regulatory factors (2008), Plant Biotechnol. J., 6, 160-175.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.247 additional information 10-100fold increase in enzyme activity of enzymes involved in the biosynthesis of morphinan alkaloids by overexpression of regulatory transcription factors, overview Eschscholzia californica
1.1.1.247 additional information 10-100fold increase in enzyme activity of enzymes involved in the biosynthesis of morphinan alkaloids by overexpression of regulatory transcription factors, overview Papaver somniferum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.247 factors involved in transcriptional regulation, overview Eschscholzia californica
1.1.1.247 factors involved in transcriptional regulation, overview Papaver somniferum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.247 additional information Papaver somniferum the enzyme is involved in biosynthesis of morphinan alkaloids, overview ?
-
 ?
1.1.1.247 additional information Eschscholzia californica the enzyme is involved in biosynthesis of morphinan alkaloids, transcriptional regulation, overview ?
-
 ?
2.1.1.116 S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine Papaver somniferum
-
 S-Adenosyl-L-homocysteine + (S)-reticuline
-
 ?
2.1.1.128 S-adenosyl-L-methionine + (RS)-norcoclaurine Papaver somniferum
-
 S-adenosyl-L-homocysteine + (RS)-coclaurine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.247 Eschscholzia californica
-
-
-
1.1.1.247 Papaver somniferum
-
-
-
2.1.1.116 Papaver somniferum
-
-
-
2.1.1.128 Papaver somniferum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.247 additional information the enzyme is involved in biosynthesis of morphinan alkaloids, overview Papaver somniferum ?
-
 ?
1.1.1.247 additional information the enzyme is involved in biosynthesis of morphinan alkaloids, transcriptional regulation, overview Eschscholzia californica ?
-
 ?
2.1.1.116 S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine
-
 Papaver somniferum S-Adenosyl-L-homocysteine + (S)-reticuline
-
 ?
2.1.1.128 S-adenosyl-L-methionine + (RS)-norcoclaurine
-
 Papaver somniferum S-adenosyl-L-homocysteine + (RS)-coclaurine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.247 codeinone reductase
-
 Eschscholzia californica
1.1.1.247 codeinone reductase
-
 Papaver somniferum
1.1.1.247 COR
-
 Eschscholzia californica
1.1.1.247 COR
-
 Papaver somniferum
2.1.1.116 Ps4'OMT
-
 Papaver somniferum
2.1.1.116 S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase
-
 Papaver somniferum
2.1.1.128 (R,S)-norcoclaurine 6-O-methyltransferase
-
 Papaver somniferum
2.1.1.128 Ps6OMT
-
 Papaver somniferum

Expression

EC Number Organism Comment Expression
2.1.1.128 Papaver somniferum the over-expression of regulatory factors AP2G, AN1-like, ERF2, GARP, MDB025 and WRKY1 increases the levels of codeinone reductase, (S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase) and (R,S)-norcoclaurine 6-O-methyltransferase transcripts by 10- to more than 100fold. The transcriptional activations translate into an enhancement of alkaloid production in opium poppy of up to at least 10fold up