EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.18.1 | 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside | THSG, tyrosinase activator isolated from Radix Polygoni multiflori | Agaricus bisporus | |
1.14.18.1 | 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside | THSG, tyrosinase activator isolated from Radix Polygoni multiflori. It significantly increases the activity of murine tyrosinase and stimulates melanin biosynthesis in B16 melanoma cells. THSG is found to be non-cytotoxic to B16 melanoma cells at a concentration of 0.1-12.5 microg/ml | Mus musculus | |
1.14.18.1 | chrysophanol | anthraquinone | Mus musculus | |
1.14.18.1 | chrysophanol | anthraquinone, slightly activates tyrosinase | Agaricus bisporus | |
1.14.18.1 | emodin | anthraquinone | Mus musculus | |
1.14.18.1 | emodin | anthraquinone, slightly activates tyrosinase | Agaricus bisporus | |
1.14.18.1 | gallic acid | - |
Mus musculus | |
1.14.18.1 | gallic acid | - |
Agaricus bisporus | |
1.14.18.1 | physcion | anthraquinone | Mus musculus | |
1.14.18.1 | physcion | anthraquinone, slightly activates tyrosinase | Agaricus bisporus |
EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.18.1 | drug development | activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases. 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside is a potent tyrosinase activator and stimulator of melanogenesis with potential for the treatment of hypopigmentation disease | Mus musculus |
1.14.18.1 | drug development | activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases. THSG is a potent tyrosinase activator and stimulator of melanogenesis with potential for the treatment of hypopigmentation disease | Agaricus bisporus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.18.1 | Agaricus bisporus | - |
- |
- |
1.14.18.1 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.18.1 | B-16 cell | - |
Mus musculus | - |
1.14.18.1 | commercial preparation | - |
Agaricus bisporus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.14.18.1 | additional information | - |
for the mushroom tyrosinase activity assay, mushroom tyrosinase with 100 U/ml is used | Agaricus bisporus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.1 | L-3,4-dihydroxyphenylalanine + 1/2 O2 | - |
Mus musculus | L-dopaquinone + H2O | - |
? | |
1.14.18.1 | L-dopa + 1/2 O2 | - |
Agaricus bisporus | L-dopachrome + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.18.1 | murine tyrosinase | from cultured B16 cells | Mus musculus |
1.14.18.1 | tyrosinase | - |
Mus musculus |
1.14.18.1 | tyrosinase | - |
Agaricus bisporus |