Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Guan, S.; Su, W.; Wang, N.; Li, P.; Wang, Y.
    A potent tyrosinase activator from Radix Polygoni multiflori and its melanogenesis stimulatory effect in B16 melanoma cells (2008), Phytother. Res., 22, 660-663.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.18.1 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside THSG, tyrosinase activator isolated from Radix Polygoni multiflori Agaricus bisporus
1.14.18.1 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside THSG, tyrosinase activator isolated from Radix Polygoni multiflori. It significantly increases the activity of murine tyrosinase and stimulates melanin biosynthesis in B16 melanoma cells. THSG is found to be non-cytotoxic to B16 melanoma cells at a concentration of 0.1-12.5 microg/ml Mus musculus
1.14.18.1 chrysophanol anthraquinone Mus musculus
1.14.18.1 chrysophanol anthraquinone, slightly activates tyrosinase Agaricus bisporus
1.14.18.1 emodin anthraquinone Mus musculus
1.14.18.1 emodin anthraquinone, slightly activates tyrosinase Agaricus bisporus
1.14.18.1 gallic acid
-
Mus musculus
1.14.18.1 gallic acid
-
Agaricus bisporus
1.14.18.1 physcion anthraquinone Mus musculus
1.14.18.1 physcion anthraquinone, slightly activates tyrosinase Agaricus bisporus

Application

EC Number Application Comment Organism
1.14.18.1 drug development activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases. 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside is a potent tyrosinase activator and stimulator of melanogenesis with potential for the treatment of hypopigmentation disease Mus musculus
1.14.18.1 drug development activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases. THSG is a potent tyrosinase activator and stimulator of melanogenesis with potential for the treatment of hypopigmentation disease Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-
1.14.18.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 B-16 cell
-
Mus musculus
-
1.14.18.1 commercial preparation
-
Agaricus bisporus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.18.1 additional information
-
for the mushroom tyrosinase activity assay, mushroom tyrosinase with 100 U/ml is used Agaricus bisporus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-3,4-dihydroxyphenylalanine + 1/2 O2
-
Mus musculus L-dopaquinone + H2O
-
?
1.14.18.1 L-dopa + 1/2 O2
-
Agaricus bisporus L-dopachrome + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 murine tyrosinase from cultured B16 cells Mus musculus
1.14.18.1 tyrosinase
-
Mus musculus
1.14.18.1 tyrosinase
-
Agaricus bisporus