Any feedback?
Literature summary extracted from
- Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum (2007), Phytother. Res., 21, 1076-1081.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | drug development | tyrosinase inhibitors can be clinically useful for the treatment of some dermatological disorders associated with melanin hyperpigmentation | Agaricus bisporus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | 2alpha,3alpha,23-trihydroxyolean-12-en-28-oic acid | pentacyclic triterpene extracted from Rhododendron collettianum | Agaricus bisporus |  |
| 1.14.18.1 | 3beta, 23, 24-trihydroxyolean-12-en-28-oic acid | pentacyclic triterpene extracted from Rhododendron collettianum | Agaricus bisporus | |
| 1.14.18.1 | arjungenin | pentacyclic triterpene extracted from Rhododendron collettianum | Agaricus bisporus | |
| 1.14.18.1 | arjunilic acid | pentacyclic triterpene extracted from Rhododendron collettianum, most potent inhibitor, have potential to be used for the treatment of hyperpigmentation associated with the high production of melanocytes | Agaricus bisporus | |
| 1.14.18.1 | bayogenin | pentacyclic triterpene extracted from Rhododendron collettianum | Agaricus bisporus | |
| 1.14.18.1 | betulinic acid | pentacyclic triterpene extracted from Rhododendron collettianum | Agaricus bisporus | |
| 1.14.18.1 | erythrodiol | pentacyclic triterpene extracted from Rhododendron collettianum | Agaricus bisporus | |
| 1.14.18.1 | kojic acid | used as a positive control | Agaricus bisporus | |
| 1.14.18.1 | L-mimosine | used as a positive control | Agaricus bisporus | |
| 1.14.18.1 | maslinic acid | pentacyclic triterpene extracted from Rhododendron collettianum | Agaricus bisporus | |
| 1.14.18.1 | methyl arjunolate | pentacyclic triterpene extracted from Rhododendron collettianum | Agaricus bisporus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | commercial preparation | - |
Agaricus bisporus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | L-dopa + 1/2 O2 | - |
Agaricus bisporus | L-dopaquinone + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | tyrosinase | - |
Agaricus bisporus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 6.8 | - |
tyrosinase inhibition assay at | Agaricus bisporus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.18.1 | 0.001 | - |
- |
Agaricus bisporus | arjunilic acid | |
| 1.14.18.1 | 0.0011 | - |
- |
Agaricus bisporus | bayogenin | |
| 1.14.18.1 | 0.00112 | - |
- |
Agaricus bisporus | 2alpha,3alpha,23-trihydroxyolean-12-en-28-oic acid | |
| 1.14.18.1 | 0.0017 | - |
- |
Agaricus bisporus | maslinic acid | |
| 1.14.18.1 | 0.00214 | - |
- |
Agaricus bisporus | betulinic acid | |
| 1.14.18.1 | 0.002345 | - |
- |
Agaricus bisporus | methyl arjunolate | |
| 1.14.18.1 | 0.00312 | - |
- |
Agaricus bisporus | erythrodiol | |
| 1.14.18.1 | 0.00368 | - |
- |
Agaricus bisporus | L-mimosine | |
| 1.14.18.1 | 0.006577 | - |
- |
Agaricus bisporus | arjungenin | |
| 1.14.18.1 | 0.01102 | - |
- |
Agaricus bisporus | 3beta, 23, 24-trihydroxyolean-12-en-28-oic acid | |
| 1.14.18.1 | 0.01667 | - |
- |
Agaricus bisporus | kojic acid | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
