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Literature summary extracted from

  • Karioti, A.; Skaltsa, H.; Zhang, X.; Tonge, P.J.; Perozzo, R.; Kaiser, M.; Franzblau, S.G.; Tasdemir, D.
    Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata (2008), Phytomedicine, 15, 1125-1129.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.100 4-acetoxyanthecotulide most active linear sesquiterpene lactone from Anthemis auriculata against FabG Plasmodium falciparum K1
1.1.1.100 4-hydroxyanthecotulide linear sesquiterpene lactone from Anthemis auriculata Plasmodium falciparum K1
1.1.1.100 anthecotulide linear sesquiterpene lactone from Anthemis auriculata Plasmodium falciparum K1
1.3.1.9 4-acetoxyanthecotulide moderate inhibition Plasmodium falciparum
1.3.1.9 4-hydroxyanthecotulide moderate inhibition Plasmodium falciparum
1.3.1.9 anthecotulide
-
Mycobacterium tuberculosis
1.3.1.9 anthecotulide moderate inhibition Plasmodium falciparum
1.3.1.9 additional information not inhibited by anthecotulide, 4-hydroxyanthecotulide, and 4-acetoxyanthecotulide Escherichia coli
1.3.1.9 additional information not inhibited by 4-hydroxyanthecotulide and 4-acetoxyanthecotulide Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.100 Plasmodium falciparum K1
-
-
-
1.3.1.9 Escherichia coli
-
strain ATCC 35218
-
1.3.1.9 Mycobacterium tuberculosis
-
-
-
1.3.1.9 Mycobacterium tuberculosis H37Rv
-
-
-
1.3.1.9 Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.100 acetoacetyl-CoA + NADPH
-
Plasmodium falciparum K1 3-hydroxybutyryl-CoA + NADP+
-
?
1.3.1.9 crotonyl-CoA + NADH + H+
-
Escherichia coli butyryl-CoA + NAD+
-
?
1.3.1.9 crotonyl-CoA + NADH + H+
-
Mycobacterium tuberculosis butyryl-CoA + NAD+
-
?
1.3.1.9 crotonyl-CoA + NADH + H+
-
Plasmodium falciparum butyryl-CoA + NAD+
-
?
1.3.1.9 crotonyl-CoA + NADH + H+
-
Mycobacterium tuberculosis H37Rv butyryl-CoA + NAD+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.100 beta-ketoacyl-ACP reductase
-
Plasmodium falciparum K1
1.1.1.100 FabG
-
Plasmodium falciparum K1
1.3.1.9 enoyl-ACP reductase
-
Escherichia coli
1.3.1.9 enoyl-ACP reductase
-
Mycobacterium tuberculosis
1.3.1.9 enoyl-ACP reductase
-
Plasmodium falciparum
1.3.1.9 FabI
-
Escherichia coli
1.3.1.9 FabI
-
Mycobacterium tuberculosis
1.3.1.9 FabI
-
Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.100 NADPH
-
Plasmodium falciparum K1
1.3.1.9 NADH
-
Escherichia coli
1.3.1.9 NADH
-
Mycobacterium tuberculosis
1.3.1.9 NADH
-
Plasmodium falciparum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.100 0.5
-
pH 7.0, 25°C Plasmodium falciparum K1 4-acetoxyanthecotulide
1.1.1.100 0.75
-
pH 7.0, 25°C Plasmodium falciparum K1 4-hydroxyanthecotulide
1.1.1.100 1
-
pH 7.0, 25°C Plasmodium falciparum K1 anthecotulide