EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.100 | 4-acetoxyanthecotulide | most active linear sesquiterpene lactone from Anthemis auriculata against FabG | Plasmodium falciparum K1 | |
1.1.1.100 | 4-hydroxyanthecotulide | linear sesquiterpene lactone from Anthemis auriculata | Plasmodium falciparum K1 | |
1.1.1.100 | anthecotulide | linear sesquiterpene lactone from Anthemis auriculata | Plasmodium falciparum K1 | |
1.3.1.9 | 4-acetoxyanthecotulide | moderate inhibition | Plasmodium falciparum | |
1.3.1.9 | 4-hydroxyanthecotulide | moderate inhibition | Plasmodium falciparum | |
1.3.1.9 | anthecotulide | - |
Mycobacterium tuberculosis | |
1.3.1.9 | anthecotulide | moderate inhibition | Plasmodium falciparum | |
1.3.1.9 | additional information | not inhibited by anthecotulide, 4-hydroxyanthecotulide, and 4-acetoxyanthecotulide | Escherichia coli | |
1.3.1.9 | additional information | not inhibited by 4-hydroxyanthecotulide and 4-acetoxyanthecotulide | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.100 | Plasmodium falciparum K1 | - |
- |
- |
1.3.1.9 | Escherichia coli | - |
strain ATCC 35218 | - |
1.3.1.9 | Mycobacterium tuberculosis | - |
- |
- |
1.3.1.9 | Mycobacterium tuberculosis H37Rv | - |
- |
- |
1.3.1.9 | Plasmodium falciparum | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.100 | acetoacetyl-CoA + NADPH | - |
Plasmodium falciparum K1 | 3-hydroxybutyryl-CoA + NADP+ | - |
? | |
1.3.1.9 | crotonyl-CoA + NADH + H+ | - |
Escherichia coli | butyryl-CoA + NAD+ | - |
? | |
1.3.1.9 | crotonyl-CoA + NADH + H+ | - |
Mycobacterium tuberculosis | butyryl-CoA + NAD+ | - |
? | |
1.3.1.9 | crotonyl-CoA + NADH + H+ | - |
Plasmodium falciparum | butyryl-CoA + NAD+ | - |
? | |
1.3.1.9 | crotonyl-CoA + NADH + H+ | - |
Mycobacterium tuberculosis H37Rv | butyryl-CoA + NAD+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.100 | beta-ketoacyl-ACP reductase | - |
Plasmodium falciparum K1 |
1.1.1.100 | FabG | - |
Plasmodium falciparum K1 |
1.3.1.9 | enoyl-ACP reductase | - |
Escherichia coli |
1.3.1.9 | enoyl-ACP reductase | - |
Mycobacterium tuberculosis |
1.3.1.9 | enoyl-ACP reductase | - |
Plasmodium falciparum |
1.3.1.9 | FabI | - |
Escherichia coli |
1.3.1.9 | FabI | - |
Mycobacterium tuberculosis |
1.3.1.9 | FabI | - |
Plasmodium falciparum |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.100 | NADPH | - |
Plasmodium falciparum K1 | |
1.3.1.9 | NADH | - |
Escherichia coli | |
1.3.1.9 | NADH | - |
Mycobacterium tuberculosis | |
1.3.1.9 | NADH | - |
Plasmodium falciparum |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.100 | 0.5 | - |
pH 7.0, 25°C | Plasmodium falciparum K1 | 4-acetoxyanthecotulide | |
1.1.1.100 | 0.75 | - |
pH 7.0, 25°C | Plasmodium falciparum K1 | 4-hydroxyanthecotulide | |
1.1.1.100 | 1 | - |
pH 7.0, 25°C | Plasmodium falciparum K1 | anthecotulide |