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Literature summary extracted from

  • Abdel-Halim, O.B.; Marzouk, A.M.; Mothana, R.; Awadh, N.
    A new tyrosinase inhibitor from Crinum yemense as potential treatment for hyperpigmentation (2008), Pharmazie, 63, 405-407.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.18.1 drug development the inhibitor could be used as a skin whitening agent, but further evaluation of its cytotoxicity should be carried out to decide if it could be used safely as a therapeutic agent Agaricus bisporus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 (+)haemanthamine
-
 Agaricus bisporus
1.14.18.1 1,10-bis(1,10-carboxyethyl) ether
-
 Agaricus bisporus
1.14.18.1 6-hydroxy-2H-pyran-3-carbaldehyde a new tyrosinase inhibitor from Crinum yemense, testing for tyrosinase inhibiting activity, based on structural similarity to kojic acid. It shows a concentration-dependant reduction in tyrosinase activity similar to kojic acid in an in vitro assay, more potent than kojic acid Agaricus bisporus
1.14.18.1 benzoic acid
-
 Agaricus bisporus
1.14.18.1 kojic acid
-
 Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-dopa + 1/2 O2
-
 Agaricus bisporus L-dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.0422
-
-
 Agaricus bisporus 6-hydroxy-2H-pyran-3-carbaldehyde
1.14.18.1 0.0752
-
-
 Agaricus bisporus kojic acid