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Literature summary extracted from

  • Stewart, M.J.; Jothivasan, V.K.; Rowan, A.S.; Wagg, J.; Hamilton, C.J.
    Mycothiol disulfide reductase: solid phase synthesis and evaluation of alternative substrate analogues (2008), Org. Biomol. Chem., 6, 385-390.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.1.15 0.113
-
 mycothione 30°C, pH 7.5 Mycobacterium tuberculosis
1.8.1.15 0.438
-
 benzyl 2-(-N-acetyl-L-cysteinyl) amino-2-deoxy-alpha-D-glucopyranoside disulfide 30°C, pH 7.5 Mycobacterium tuberculosis
1.8.1.15 0.463
-
 2-(-N-acetyl-L-cysteinyl) amino-2-deoxy-alpha-D-glucopyranoside disulfide 30°C, pH 7.5 Mycobacterium tuberculosis
1.8.1.15 0.61
-
 methyl 2-(-N-acetyl-L-cysteinyl) amino-2-deoxy-alpha-D-glucopyranoside disulfide 30°C, pH 7.5 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.15 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.15 2-(-N-acetyl-L-cysteinyl) amino-2-deoxy-alpha-D-glucopyranoside disulfide + NADPH
-
 Mycobacterium tuberculosis ?
-
 ?
1.8.1.15 benzyl 2-(-N-acetyl-L-cysteinyl) amino-2-deoxy-alpha-D-glucopyranoside disulfide + NADPH
-
 Mycobacterium tuberculosis ?
-
 ?
1.8.1.15 methyl 2-(-N-acetyl-L-cysteinyl) amino-2-deoxy-alpha-D-glucopyranoside disulfide + NADPH
-
 Mycobacterium tuberculosis ?
-
 ?
1.8.1.15 mycothione + NADPH
-
 Mycobacterium tuberculosis mycothiol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.15 mycothiol disulfide reductase
-
 Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.1.15 25.54
-
 methyl 2-(-N-acetyl-L-cysteinyl) amino-2-deoxy-alpha-D-glucopyranoside disulfide 30°C, pH 7.5 Mycobacterium tuberculosis
1.8.1.15 36.99
-
 benzyl 2-(-N-acetyl-L-cysteinyl) amino-2-deoxy-alpha-D-glucopyranoside disulfide 30°C, pH 7.5 Mycobacterium tuberculosis
1.8.1.15 68.76
-
 mycothione 30°C, pH 7.5 Mycobacterium tuberculosis
1.8.1.15 70.05
-
 2-(-N-acetyl-L-cysteinyl) amino-2-deoxy-alpha-D-glucopyranoside disulfide 30°C, pH 7.5 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.15 NADPH
-
 Mycobacterium tuberculosis