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Literature summary extracted from
- Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans (2006), Oral Microbiol. Immunol., 21, 145-150.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.3.1 | dexamethasone | augments arginase activity in Actinobacillus actinomycetemcomitans-lipopolysaccharide-stimulated cells | Mus musculus |  |
| 3.5.3.1 | interleukin-4 | augments arginase activity in Actinobacillus actinomycetemcomitans-lipopolysaccharide-stimulated cells | Mus musculus | |
| 3.5.3.1 | lipopolysaccharide | lipopolysaccharide from Actinobacillus actinomycetemcomitans or Escherichia coli | Mus musculus | |
| 3.5.3.1 | additional information | interferon-gamma does not augment arginase activity in Actinobacillus actinomycetemcomitans lipopolysaccharide-stimulated cells | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.3.1 | L-norvaline | blocks arginase activity in Actinobacillus actinomycetemcomitans-lipopolysaccharide-stimulated cells | Mus musculus | |
| 3.5.3.1 | additional information | cell treatment with anti-CD14 and anti-toll-like receptor 4 but not anti-toll-like receptor 2 antibody decreases arginase activity in Actinobacillus actinomycetemcomitans-lipopolysaccharide-stimulated cells; DL-norvaline does not block arginase activity in Actinobacillus actinomycetemcomitans-lipopolysaccharide-stimulated cells | Mus musculus | |
| 3.5.3.1 | Polymyxin B | blocks arginase activity in Actinobacillus actinomycetemcomitans-lipopolysaccharide-stimulated cells | Mus musculus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.3.1 | L-arginine + H2O | Mus musculus | - |
L-ornithine + urea | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.3.1 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.3.1 | macrophage | - |
Mus musculus | - |
| 3.5.3.1 | RAW264.7 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.3.1 | L-arginine + H2O | - |
Mus musculus | L-ornithine + urea | - |
? | |
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