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Literature summary extracted from

  • Simonian, A.; Khomutov, A.; Hyvonen, T.; Grigorenko, N.; Keinanen, T.; Vepsalainen, J.; Alhonen, L.; Janne, J.
    Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase (2007), Nucleosides Nucleotides Nucleic Acids, 26, 1245-1248.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine Homo sapiens
-
 CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine Homo sapiens
-
 CoA + N1-acetylspermine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Homo sapiens P21673
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.57 additional information
-
 structure of polyamine fragment of the conjugate important for enzyme activity, existence of adenosine groups crucial for effective inhibition, since conjugates of D-N-pantothenylamidoethyl mercaptane family reveals low inhibitory activities, most exact mimic of the intermediate of N1-acetyltransferase reaction less active than analogue of the intermediate of N8-acetyltransferase reaction, significant contribution of the polyamine fragment into inhibition proven by lower activity Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermidine mimics of transition state of SSAT1 reaction analyzed Homo sapiens CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?
2.3.1.57 acetyl-CoA + spermine mimics of transition state of SSAT1 reaction analyzed Homo sapiens CoA + N1-acetylspermine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.57 spermidine/spermine N1-acetyltransferase 1
-
 Homo sapiens
2.3.1.57 SSAT1
-
 Homo sapiens