EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.11.67 | overexpression of FLAG-tagged CG15835 in S2 cells | Drosophila melanogaster |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.11.67 | nucleus | - |
Drosophila melanogaster | 5634 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.67 | Fe2+ | activates, required | Drosophila melanogaster |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.67 | additional information | Drosophila melanogaster | isoform dJMJD2(1)/CG15835 regulates heterochromatin organization. It is excluded from heterochromatin and localizes to multiple euchromatic sites, where it regulates trimethylated histone 3 lysine 36 methylation | ? | - |
? | |
1.14.11.67 | [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 | Drosophila melanogaster | - |
[histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
1.14.11.67 | [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | Drosophila melanogaster | - |
[histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.67 | Drosophila melanogaster | - |
- |
- |
1.14.11.67 | Drosophila melanogaster | Q9V333 | isoform dJMJD2(1)/CG15835 | - |
1.14.11.67 | Drosophila melanogaster | Q9V6L0 | isoform dJMJD2(2)/CG33182 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.67 | additional information | isoform dJMJD2(1)/CG15835 regulates heterochromatin organization. It is excluded from heterochromatin and localizes to multiple euchromatic sites, where it regulates trimethylated histone 3 lysine 36 methylation | Drosophila melanogaster | ? | - |
? | |
1.14.11.67 | additional information | demethylase activity of dJMJD2(1)/CG15835 depends on the JmjC domain. No activity with H3K4me3 and H3K27me3 by dJMJD2(1)/CG15835 and dJMJD2(2)/CG33182 | Drosophila melanogaster | ? | - |
? | |
1.14.11.67 | trimethyl-histone 3 L-lysine 36 + alpha-ketoglutarate + O2 | - |
Drosophila melanogaster | dimethyl-histone 3 L-lysine 36 + ? | - |
? | |
1.14.11.67 | [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 | - |
Drosophila melanogaster | [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
1.14.11.67 | [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 | dJMJD2(1)/CG15835 and dJMJD2(2)/CG33182 demethylate both H3K9me3 and H3K36me3 | Drosophila melanogaster | [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
1.14.11.67 | [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | - |
Drosophila melanogaster | [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
1.14.11.67 | [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | dJMJD2(1)/CG15835 and dJMJD2(2)/CG33182 demethylate both H3K9me3 and H3K36me3 | Drosophila melanogaster | [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.14.11.67 | More | domain organization and sequence homology analysis of JmjC+N proteins, overview | Drosophila melanogaster |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.11.67 | CG33182 | - |
Drosophila melanogaster |
1.14.11.67 | CG33185 | - |
Drosophila melanogaster |
1.14.11.67 | dJMJD2(1) | - |
Drosophila melanogaster |
1.14.11.67 | dJMJD2(1)/CG15835 | - |
Drosophila melanogaster |
1.14.11.67 | dJMJD2(2) | - |
Drosophila melanogaster |
1.14.11.67 | dJMJD2(2)/CG33182 | - |
Drosophila melanogaster |
1.14.11.67 | JmjC domain-containing histone demethylation protein 3A | - |
Drosophila melanogaster |
1.14.11.67 | JmjC domain-containing histone demethylation protein 3b | - |
Drosophila melanogaster |
1.14.11.67 | JmjC+N | - |
Drosophila melanogaster |
1.14.11.67 | JmjC+N histone demethylase | - |
Drosophila melanogaster |
1.14.11.67 | More | the isozymes belongs to the JmjC+N protein family, CG33182 and CG33185 are JMJD2 proteins | Drosophila melanogaster |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.14.11.67 | Drosophila melanogaster | CG15835 overexpression induces spreading of HP1, out of heterochromatin, into euchromatin, without affecting the actual pattern of histone modifications of heterochromatin. Overexpression of dJMJD2(1)/CG15835 results in a strong decrease on the levels of H3K9me3 and H3K36me3, but it does not show any significant effect on the extent of H3K9me3 and H3K9me2 at the chromocentre | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.11.67 | physiological function | dJMJD2(1)/CG15835 is excluded from heterochromatin and localizes to multiple euchromatic sites, where it regulates H3K36 methylation and heterochromatin organization. CG15835 contributes to delimit hetero- and euchromatic territories through the regulation of H3K36 methylation in euchromatin | Drosophila melanogaster |