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Literature summary extracted from

  • Arakaki, T.L.; Buckner, F.S.; Gillespie, J.R.; Malmquist, N.A.; Phillips, M.A.; Kalyuzhniy, O.; Luft, J.R.; Detitta, G.T.; Verlinde, C.L.; Van Voorhis, W.C.; Hol, W.G.; Merritt, E.A.
    Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies (2008), Mol. Microbiol., 68, 37-50.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.98.1 3,4-dihydroxybenzoate competitive inhibition at 1 mM Trypanosoma brucei
1.3.98.1 3,5-Dihydroxybenzoate non-competitive inhibition at 1 mM Trypanosoma brucei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.98.1 0.014
-
 S-dihydroorotate
-
 Trypanosoma brucei
1.3.98.1 0.08
-
 fumarate
-
 Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
1.3.98.1 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.98.1 additional information does not perform electron transfer to menaquinone, Q0, Q1, Q2, QD, O2, or to NAD+ Trypanosoma brucei ?
-
 ?
1.3.98.1 S-dihydroorotate + 2,6-dichlorophenolindophenol
-
 Trypanosoma brucei orotate + reduced 2,6-dichlorophenolindophenol
-
 ?
1.3.98.1 S-dihydroorotate + fumarate 100% activity Trypanosoma brucei orotate + succinate
-
 ?
1.3.98.1 S-dihydroorotate + menadione 20% activity with menadione compared to fumarate Trypanosoma brucei orotate + menadiol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.98.1 class 1A DHODH
-
 Trypanosoma brucei

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.98.1 8.5
-
 fumarate apparent value Trypanosoma brucei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.98.1 7.8
-
-
 Trypanosoma brucei

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.98.1 FMN
-
 Trypanosoma brucei