EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.180 | (2R)-5-hydroxy-2,4-dimethyl-2-[(1E)-2-methylbuta-1,3-dien-1-yl]thiophen-3(2H)-one | - |
Mycobacterium tuberculosis | |
2.3.1.180 | (5R)-4-hydroxy-3,5-dimethyl-5-tetradecylthiophen-2(5H)-one | - |
Mycobacterium tuberculosis | |
2.3.1.180 | (5R)-4-hydroxy-3,5-dimethyl-5-tridecylthiophen-2(5H)-one | - |
Mycobacterium tuberculosis | |
2.3.1.180 | (5R)-4-hydroxy-5-[[4'-(hydroxymethyl)biphenyl-4-yl]methyl]-3,5-dimethylthiophen-2(5H)-one | - |
Mycobacterium tuberculosis | |
2.3.1.180 | (5R)-5-dodecyl-4-hydroxy-3,5-dimethylthiophen-2(5H)-one | - |
Mycobacterium tuberculosis | |
2.3.1.180 | (5R)-5-[3-(4-acetyl-3-hydroxyphenyl)prop-2-yn-1-yl]-4-hydroxy-3,5-dimethylthiophen-2(5H)-one | - |
Mycobacterium tuberculosis | |
2.3.1.180 | (5R)-5-[3-(4-acetylphenyl)prop-2-yn-1-yl]-4-hydroxy-3,5-dimethylthiophen-2(5H)-one | - |
Mycobacterium tuberculosis | |
2.3.1.180 | 1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid | - |
Escherichia coli | |
2.3.1.180 | 1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid | - |
Haemophilus influenzae | |
2.3.1.180 | 1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid | - |
Escherichia coli | |
2.3.1.180 | 1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid | - |
Haemophilus influenzae | |
2.3.1.180 | 2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid | - |
Escherichia coli | |
2.3.1.180 | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | - |
Enterococcus faecium | |
2.3.1.180 | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | - |
Escherichia coli | |
2.3.1.180 | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | - |
Haemophilus influenzae | |
2.3.1.180 | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | - |
Neisseria meningitidis | |
2.3.1.180 | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | - |
Staphylococcus aureus | |
2.3.1.180 | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | - |
Streptococcus pneumoniae | |
2.3.1.180 | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | - |
Streptococcus pyogenes | |
2.3.1.180 | 2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]benzoic acid | - |
Escherichia coli | |
2.3.1.180 | 2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]benzoic acid | - |
Escherichia coli | |
2.3.1.180 | 2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid | - |
Enterococcus faecium | |
2.3.1.180 | 2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid | - |
Escherichia coli | |
2.3.1.180 | 2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid | - |
Neisseria meningitidis | |
2.3.1.180 | 2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid | - |
Staphylococcus aureus | |
2.3.1.180 | 2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid | - |
Streptococcus pneumoniae | |
2.3.1.180 | 2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid | - |
Streptococcus pyogenes | |
2.3.1.180 | 4,5-dichloro-3H-1,2-dithiol-3-one | - |
Staphylococcus aureus | |
2.3.1.180 | 4,5-dichloro-3H-1,2-dithiole-3-thione | - |
Staphylococcus aureus | |
2.3.1.180 | 5-chloro-4-phenyl-3H-1,2-dithiol-3-one | - |
Staphylococcus aureus | |
2.3.1.180 | thiolactomycin | - |
Escherichia coli | |
2.3.1.180 | thiolactomycin | - |
Haemophilus influenzae | |
2.3.1.180 | thiolactomycin | - |
Streptococcus pneumoniae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.180 | Enterococcus faecium | - |
- |
- |
2.3.1.180 | Escherichia coli | - |
- |
- |
2.3.1.180 | Haemophilus influenzae | - |
- |
- |
2.3.1.180 | Mycobacterium tuberculosis | - |
- |
- |
2.3.1.180 | Neisseria meningitidis | - |
- |
- |
2.3.1.180 | Pseudomonas aeruginosa | - |
- |
- |
2.3.1.180 | Staphylococcus aureus | - |
- |
- |
2.3.1.180 | Streptococcus pneumoniae | - |
- |
- |
2.3.1.180 | Streptococcus pyogenes | - |
- |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.180 | ecFabH | - |
Escherichia coli |
2.3.1.180 | efFabH | - |
Enterococcus faecium |
2.3.1.180 | hiFabH | - |
Haemophilus influenzae |
2.3.1.180 | mtFabH | - |
Mycobacterium tuberculosis |
2.3.1.180 | nmFabH | - |
Neisseria meningitidis |
2.3.1.180 | paFabH | - |
Pseudomonas aeruginosa |
2.3.1.180 | saFabH | - |
Staphylococcus aureus |
2.3.1.180 | spFabH | - |
Streptococcus pneumoniae |
2.3.1.180 | spyFabH | - |
Streptococcus pneumoniae |
2.3.1.180 | spyFabH | - |
Streptococcus pyogenes |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.180 | 0.000004 | - |
- |
Streptococcus pyogenes | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | |
2.3.1.180 | 0.000004 | - |
- |
Enterococcus faecium | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | |
2.3.1.180 | 0.00004 | - |
- |
Haemophilus influenzae | 1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid | |
2.3.1.180 | 0.00014 | - |
- |
Escherichia coli | 1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid | |
2.3.1.180 | 0.00088 | - |
- |
Escherichia coli | 1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid | |
2.3.1.180 | 0.001 | - |
- |
Escherichia coli | 2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]benzoic acid | |
2.3.1.180 | 0.0014 | - |
- |
Escherichia coli | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | |
2.3.1.180 | 0.00192 | - |
- |
Staphylococcus aureus | 5-chloro-4-phenyl-3H-1,2-dithiol-3-one | |
2.3.1.180 | 0.002 | - |
- |
Escherichia coli | 2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]benzoic acid | |
2.3.1.180 | 0.00225 | - |
- |
Staphylococcus aureus | 4,5-dichloro-3H-1,2-dithiol-3-one | |
2.3.1.180 | 0.0024 | - |
- |
Haemophilus influenzae | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | |
2.3.1.180 | 0.00319 | - |
- |
Staphylococcus aureus | 4,5-dichloro-3H-1,2-dithiole-3-thione | |
2.3.1.180 | 0.0038 | - |
- |
Staphylococcus aureus | 2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid | |
2.3.1.180 | 0.00404 | - |
- |
Mycobacterium tuberculosis | (5R)-5-[3-(4-acetylphenyl)prop-2-yn-1-yl]-4-hydroxy-3,5-dimethylthiophen-2(5H)-one | |
2.3.1.180 | 0.0057 | - |
- |
Escherichia coli | 2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid | |
2.3.1.180 | 0.007 | - |
- |
Haemophilus influenzae | 1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid | |
2.3.1.180 | 0.00702 | - |
- |
Mycobacterium tuberculosis | (5R)-5-[3-(4-acetyl-3-hydroxyphenyl)prop-2-yn-1-yl]-4-hydroxy-3,5-dimethylthiophen-2(5H)-one | |
2.3.1.180 | 0.017 | - |
- |
Mycobacterium tuberculosis | (5R)-4-hydroxy-5-[[4'-(hydroxymethyl)biphenyl-4-yl]methyl]-3,5-dimethylthiophen-2(5H)-one | |
2.3.1.180 | 0.019 | - |
- |
Mycobacterium tuberculosis | (5R)-4-hydroxy-5-[[4'-(hydroxymethyl)biphenyl-4-yl]methyl]-3,5-dimethylthiophen-2(5H)-one | |
2.3.1.180 | 0.04 | - |
- |
Mycobacterium tuberculosis | (5R)-5-dodecyl-4-hydroxy-3,5-dimethylthiophen-2(5H)-one | |
2.3.1.180 | 0.08 | - |
- |
Mycobacterium tuberculosis | (5R)-4-hydroxy-3,5-dimethyl-5-tetradecylthiophen-2(5H)-one | |
2.3.1.180 | 0.08 | - |
- |
Mycobacterium tuberculosis | (5R)-4-hydroxy-3,5-dimethyl-5-tridecylthiophen-2(5H)-one | |
2.3.1.180 | 0.11 | - |
- |
Escherichia coli | thiolactomycin |