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Literature summary extracted from

  • Pye, V.E.; Dreveny, I.; Briggs, L.C.; Sands, C.; Beuron, F.; Zhang, X.; Freemont, P.S.
    Going through the motions: The ATPase cycle of p97 (2006), J. Struct. Biol., 156, 12-28.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.4.6 additional information activity is dependent upon hexamerisation Drosophila melanogaster
3.6.4.6 additional information activity is dependent upon hexamerisation Saccharomyces cerevisiae
3.6.4.6 additional information activity is dependent upon hexamerisation Arabidopsis thaliana
3.6.4.6 additional information activity is dependent upon hexamerisation Archaea
3.6.4.6 additional information activity is dependent upon hexamerisation protozoa

Application

EC Number Application Comment Organism
3.6.4.6 medicine dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases Drosophila melanogaster
3.6.4.6 medicine dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases Saccharomyces cerevisiae
3.6.4.6 medicine dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases Arabidopsis thaliana
3.6.4.6 medicine dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases Archaea
3.6.4.6 medicine dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases protozoa

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.4.6
-
 Drosophila melanogaster
3.6.4.6
-
 Saccharomyces cerevisiae
3.6.4.6
-
 Arabidopsis thaliana
3.6.4.6
-
 Archaea
3.6.4.6
-
 protozoa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.4.6 Mg2+
-
 Drosophila melanogaster
3.6.4.6 Mg2+
-
 Saccharomyces cerevisiae
3.6.4.6 Mg2+
-
 Arabidopsis thaliana
3.6.4.6 Mg2+
-
 Archaea
3.6.4.6 Mg2+
-
 protozoa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.4.6 ATP + H2O Drosophila melanogaster
-
 ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O Saccharomyces cerevisiae
-
 ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O Arabidopsis thaliana
-
 ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O Archaea
-
 ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O protozoa
-
 ADP + phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
3.6.4.6 Arabidopsis thaliana
-
-
-
3.6.4.6 Archaea
-
-
-
3.6.4.6 Drosophila melanogaster
-
-
-
3.6.4.6 protozoa
-
-
-
3.6.4.6 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.4.6 ATP + H2O
-
 Drosophila melanogaster ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O
-
 Saccharomyces cerevisiae ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O
-
 Arabidopsis thaliana ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O
-
 Archaea ADP + phosphate
-
 ir
3.6.4.6 ATP + H2O
-
 protozoa ADP + phosphate
-
 ir

Subunits

EC Number Subunits Comment Organism
3.6.4.6 hexamer
-
 Drosophila melanogaster
3.6.4.6 hexamer
-
 Saccharomyces cerevisiae
3.6.4.6 hexamer
-
 Arabidopsis thaliana
3.6.4.6 hexamer
-
 Archaea
3.6.4.6 hexamer
-
 protozoa

Synonyms

EC Number Synonyms Comment Organism
3.6.4.6 Cdc48
-
 Drosophila melanogaster
3.6.4.6 Cdc48
-
 Saccharomyces cerevisiae
3.6.4.6 Cdc48
-
 Arabidopsis thaliana
3.6.4.6 Cdc48
-
 Archaea
3.6.4.6 Cdc48
-
 protozoa
3.6.4.6 p97
-
 Drosophila melanogaster
3.6.4.6 p97
-
 Saccharomyces cerevisiae
3.6.4.6 p97
-
 Arabidopsis thaliana
3.6.4.6 p97
-
 Archaea
3.6.4.6 p97
-
 protozoa
3.6.4.6 VCP
-
 Drosophila melanogaster
3.6.4.6 VCP
-
 Saccharomyces cerevisiae
3.6.4.6 VCP
-
 Arabidopsis thaliana
3.6.4.6 VCP
-
 Archaea
3.6.4.6 VCP
-
 protozoa