Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Talukdar, A.; Illarionov, B.; Bacher, A.; Fischer, M.; Cushman, M.
    Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase (2007), J. Org. Chem., 72, 7167-7175.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.78 molecular modeling of enzyme with inhibitor 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione Bacillus subtilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.9 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride
-
 Escherichia coli
2.5.1.9 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride
-
 Mycobacterium tuberculosis
2.5.1.9 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione
-
 Escherichia coli
2.5.1.9 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione
-
 Mycobacterium tuberculosis
2.5.1.78 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride inhibition of both lumazine synthase and riboflavin synthase Bacillus subtilis
2.5.1.78 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride inhibition of both lumazine synthase and riboflavin synthase Mycobacterium tuberculosis
2.5.1.78 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride inhibition of both lumazine synthase and riboflavin synthase Schizosaccharomyces pombe
2.5.1.78 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione inhibition of both lumazine synthase and riboflavin synthase Bacillus subtilis
2.5.1.78 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione inhibition of both lumazine synthase and riboflavin synthase Mycobacterium tuberculosis
2.5.1.78 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione inhibition of both lumazine synthase and riboflavin synthase Schizosaccharomyces pombe

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.9 Escherichia coli
-
-
-
2.5.1.9 Mycobacterium tuberculosis
-
-
-
2.5.1.78 Bacillus subtilis
-
-
-
2.5.1.78 Mycobacterium tuberculosis
-
-
-
2.5.1.78 Schizosaccharomyces pombe
-
-
-

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.78 27
-
 assay at Bacillus subtilis
2.5.1.78 27
-
 assay at Schizosaccharomyces pombe
2.5.1.78 37
-
 assay at Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.78 7
-
 assay at Bacillus subtilis
2.5.1.78 7
-
 assay at Schizosaccharomyces pombe
2.5.1.78 7
-
 assay at Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.9 0.00056
-
 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione pH 7.0, 27°C Mycobacterium tuberculosis
2.5.1.9 0.0025
-
 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride pH 7.0, 27°C Mycobacterium tuberculosis
2.5.1.9 0.0027
-
 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione pH 7.0, 27°C Escherichia coli
2.5.1.9 0.047
-
 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride pH 7.0, 27°C Escherichia coli
2.5.1.78 0.00016
-
 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride pH 7.0, 27°C Schizosaccharomyces pombe
2.5.1.78 0.002
-
 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione pH 7.0, 27°C Schizosaccharomyces pombe
2.5.1.78 0.0026
-
 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride pH 7.0, 27°C Bacillus subtilis
2.5.1.78 0.011
-
 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione pH 7.0, 27°C Mycobacterium tuberculosis
2.5.1.78 0.026
-
 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione pH 7.0, 27°C Bacillus subtilis
2.5.1.78 0.031
-
 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride pH 7.0, 27°C Mycobacterium tuberculosis