Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sunal, S.G.; Yabanoglu, S.; Yesilada, A.; Ucar, G.
    Monoamine oxidase inhibitory activities of novel 3,4-dihydroquinolin-(1H)-2-one derivatives (2007), J. Neural Transm., 114, 717-719.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 1-(benzylideneamino)-3,4-dihydroquinolin-2(1H)-one selective for MAO-B Rattus norvegicus
1.4.3.4 1-amino-3,4-dihydroquinolin-2(1H)-one selective for MAO-B Rattus norvegicus
1.4.3.4 2-(4-chlorophenyl)-N-cyclohexyl-2-(3-ethynyl-2-oxo-4-phenylquinolin-1(2H)-yl)acetamide selective for MAO-B Rattus norvegicus
1.4.3.4 paragyline
-
 Rattus norvegicus
1.4.3.4 Pargyline
-
 Rattus norvegicus
1.4.3.4 tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl](phenyl)amino]-2-oxoethyl)carbamate non-selective; non-selective Rattus norvegicus
1.4.3.4 tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl][2-(phenylcarbonyl)phenyl]amino]-2-oxoethyl)carbamate selective for MAO-B Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Rattus norvegicus P19643
-
-
1.4.3.4 Rattus norvegicus P21396
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.4
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 tyramine + H2O + O2
-
 Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Rattus norvegicus
1.4.3.4 MAO-B
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 0.00272
-
-
 Rattus norvegicus Pargyline
1.4.3.4 0.00405
-
-
 Rattus norvegicus paragyline
1.4.3.4 0.06
-
 37°C, no preincubation Rattus norvegicus 1-amino-3,4-dihydroquinolin-2(1H)-one
1.4.3.4 0.063
-
 37°C, no preincubation Rattus norvegicus 2-(4-chlorophenyl)-N-cyclohexyl-2-(3-ethynyl-2-oxo-4-phenylquinolin-1(2H)-yl)acetamide
1.4.3.4 0.066
-
 37°C, no preincubation Rattus norvegicus 1-(benzylideneamino)-3,4-dihydroquinolin-2(1H)-one
1.4.3.4 0.079
-
 37°C, no preincubation Rattus norvegicus tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl][2-(phenylcarbonyl)phenyl]amino]-2-oxoethyl)carbamate
1.4.3.4 0.25
-
 37°C, no preincubation Rattus norvegicus tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl](phenyl)amino]-2-oxoethyl)carbamate
1.4.3.4 0.33
-
 37°C, no preincubation Rattus norvegicus tert-butyl (2-[[2-(cyclohexylamino)-1-(3-hydroxyphenyl)-2-oxoethyl](phenyl)amino]-2-oxoethyl)carbamate