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Literature summary extracted from

  • Szoecs, K.; Lassegue, B.; Wenzel, P.; Wendt, M.; Daiber, A.; Oelze, M.; Meinertz, T.; Muenzel, T.; Baldus, S.
    Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation (2007), J. Mol. Cell. Cardiol., 42, 1111-1118.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.3.1 nitroglycerin in vascular smooth muscle cells exposed to nitroglycerin for 6-24 h, NAD(P)H oxidase activity is increased, in spite of isoform nox1 downregulation Rattus norvegicus

Application

EC Number Application Comment Organism
1.2.1.5 additional information ALDH2 may have antioxidant properties. Yeast ALDH significantly and dose-dependently attenuates HX/XO-generated O2S- signal Saccharomyces cerevisiae
1.2.1.5 additional information reduced ALDH-2 activity and expression leads to decreased nitroglycerin bioconversion. ALDH is an important physiological inhibitory factor of superoxide production Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.5 benomyl potent irreversible inhibitor of ALDH. Benomyl increases superoxide production as much as nitroglycerin Rattus norvegicus
1.2.1.5 nitroglycerin induces nitrate tolerance. Expression and activity of ALDH-2 is decreased in nitrate-tolerant rats Rattus norvegicus
1.6.3.1 nitroglycerin in rats treated with nitroglycerin for three days, superoxide production is increased in all aortic layers, while expression of isoforms nox1, nox2 and nox4 is significantly decreased. In vascular smooth muscle cells exposed to nitroglycerin for 6-24 h, NAD(P)H oxidase activity is increased, in spite of nox1 downregulation Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.5 Rattus norvegicus P11884 male Wistar rats
-
1.2.1.5 Saccharomyces cerevisiae
-
-
-
1.6.3.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.5 aorta
-
Rattus norvegicus
-
1.2.1.5 additional information addition of ALDH to RASM cell homogenates significantly decreases NO consumption Rattus norvegicus
-
1.2.1.5 smooth muscle
-
Rattus norvegicus
-
1.6.3.1 aortic smooth muscle cell commercial preparation Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.5 benzaldehyde + NADP+ + H2O
-
Saccharomyces cerevisiae benzoate + NADPH + H+
-
?
1.2.1.5 benzaldehyde + NADP+ + H2O
-
Rattus norvegicus benzoate + NADPH + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.5 aldehyde dehydrogenase 2
-
Saccharomyces cerevisiae
1.2.1.5 aldehyde dehydrogenase 2
-
Rattus norvegicus
1.2.1.5 ALDH2
-
Saccharomyces cerevisiae
1.2.1.5 ALDH2
-
Rattus norvegicus