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Literature summary extracted from

  • Cynis, H.; Rahfeld, J.U.; Stephan, A.; Kehlen, A.; Koch, B.; Wermann, M.; Demuth, H.U.; Schilling, S.
    Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery (2008), J. Mol. Biol., 379, 966-980.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.5 h-isoQC, lacking the N-terminal signal anchor and the short cytosolic tail, is expressed as a fusion protein in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.5 1,10-phenanthroline
-
 Homo sapiens
2.3.2.5 benzimidazole
-
 Homo sapiens
2.3.2.5 benzylimidazole
-
 Homo sapiens
2.3.2.5 cysteamine
-
 Homo sapiens
2.3.2.5 EDTA
-
 Homo sapiens
2.3.2.5 H-Gln-7-amido-4-methylcoumarin substrate inhibition Homo sapiens
2.3.2.5 H-Gln-beta-naphthylamide substrate inhibition Homo sapiens
2.3.2.5 imidazole
-
 Homo sapiens
2.3.2.5 methylimidazole
-
 Homo sapiens
2.3.2.5 N-dimethylcysteamine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.5 0.017
-
 H-Gln-7-amido-4-methylcoumarin pH 8.0, 30°C Homo sapiens
2.3.2.5 0.036
-
 H-Gln-beta-naphthylamide pH 8.0, 30°C Homo sapiens
2.3.2.5 0.115
-
 H-Gln-Gln-OH pH 8.0, 30°C Homo sapiens
2.3.2.5 0.214
-
 H-Gln-Gly-Pro-OH pH 8.0, 30°C Homo sapiens
2.3.2.5 0.424
-
 H-Gln-Gly-OH pH 8.0, 30°C Homo sapiens
2.3.2.5 0.705
-
 H-Gln-Glu-OH pH 8.0, 30°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.5 Golgi apparatus exclusively localized within the Golgi complex, obviously retained by the N-terminus. Retention in the Golgi complex suggests involvement in the protein maturation machinery Homo sapiens 5794
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.5 additional information ubiquitous expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.5 Gln-Gln
-
 Homo sapiens 5-oxoprolyl-Gln + NH3
-
 ?
2.3.2.5 Gln-Gly
-
 Homo sapiens 5-oxoprolyl-Gly + NH3
-
 ?
2.3.2.5 H-Gln-7-amido-4-methylcoumarin
-
 Homo sapiens 5-oxoprolyl-7-amido-4-methylcoumarin + NH3
-
 ?
2.3.2.5 H-Gln-beta-naphthylamide
-
 Homo sapiens 5-oxoprolyl-beta-naphthylamide + NH3
-
 ?
2.3.2.5 H-Gln-Glu-OH
-
 Homo sapiens 5-oxoprolyl-Glu-OH + NH3
-
 ?
2.3.2.5 H-Gln-Gly-Pro-OH
-
 Homo sapiens 5-oxoprolyl-Gly-Pro-OH + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.5 glutaminyl cyclase
-
 Homo sapiens
2.3.2.5 h-isoQC
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.2.5 1.07
-
 H-Gln-7-amido-4-methylcoumarin pH 8.0, 30°C Homo sapiens
2.3.2.5 1.66
-
 H-Gln-Gly-OH pH 8.0, 30°C Homo sapiens
2.3.2.5 2.65
-
 H-Gln-Glu-OH pH 8.0, 30°C Homo sapiens
2.3.2.5 2.72
-
 H-Gln-Gln-OH pH 8.0, 30°C Homo sapiens
2.3.2.5 3.4
-
 H-Gln-beta-naphthylamide pH 8.0, 30°C Homo sapiens
2.3.2.5 4.02
-
 H-Gln-Gly-Pro-OH pH 8.0, 30°C Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.2.5 0.0073
-
 benzylimidazole pH 8.0, 30°C Homo sapiens
2.3.2.5 0.022
-
 N-dimethylcysteamine pH 8.0, 30°C Homo sapiens
2.3.2.5 0.068
-
 cysteamine pH 8.0, 30°C Homo sapiens
2.3.2.5 0.079
-
 methylimidazole pH 8.0, 30°C Homo sapiens
2.3.2.5 0.199
-
 benzimidazole pH 8.0, 30°C Homo sapiens
2.3.2.5 0.219
-
 imidazole pH 8.0, 30°C Homo sapiens
2.3.2.5 1.47
-
 H-Gln-beta-naphthylamide
-
 Homo sapiens
2.3.2.5 5.73
-
 H-Gln-7-amido-4-methylcoumarin
-
 Homo sapiens