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Literature summary extracted from

  • Ryu, Y.B.; Ha, T.J.; Curtis-Long, M.J.; Ryu, H.W.; Gal, S.W.; Park, K.H.
    Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz (2008), J. Enzyme Inhib. Med. Chem., 23, 922-930.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 cyclomorusin exhibits competitive inhibition characteristics. Flavone displaying tyrosinase inhibitory activity, isolated from the stem barks of Morus lhou. Inhibitory potency of this flavonoid toward monophenolase activity of mushroom tyrosinase is investigated Agaricus bisporus
1.14.18.1 kuwanon C exhibits competitive inhibition characteristics. Flavone displaying tyrosinase inhibitory activity, isolated from the stem barks of Morus lhou. Inhibitory potency of this flavonoid toward monophenolase activity of mushroom tyrosinase is investigated Agaricus bisporus
1.14.18.1 mormin exhibits competitive inhibition characteristics. Characterized as a new flavone possesing a 3-hydroxymethyl-2-butenyl at C-3. Flavone displaying tyrosinase inhibitory activity, isolated from the stem barks of Morus lhou. Inhibitory potency of this flavonoid toward monophenolase activity of mushroom tyrosinase is investigated Agaricus bisporus
1.14.18.1 morusin Flavone displaying tyrosinase inhibitory activity, isolated from the stem barks of Morus lhou. Inhibitory potency of this flavonoid toward monophenolase activity of mushroom tyrosinase is investigated Agaricus bisporus
1.14.18.1 norartocarpetin exhibits competitive inhibition characteristics. Flavone displaying tyrosinase inhibitory activity, isolated from the stem barks of Morus lhou. Inhibitory potency of this flavonoid toward monophenolase activity of mushroom tyrosinase is investigated. Norartocarpetin shows a time-dependent inhibition against oxidation of l-tyrosine. It also operated under the enzyme isomerization model Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 monophenolase
-
 Agaricus bisporus
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.0012
-
 for monophenolase activity Agaricus bisporus norartocarpetin
1.14.18.1 0.088
-
 for monophenolase activity Agaricus bisporus mormin
1.14.18.1 0.092
-
 for monophenolase activity Agaricus bisporus cyclomorusin
1.14.18.1 0.135
-
 for monophenolase activity Agaricus bisporus kuwanon C
1.14.18.1 0.25
-
 for monophenolase activity Agaricus bisporus morusin