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Literature summary extracted from

  • Marcos, N.T.; Magalhaes, A.; Ferreira, B.; Oliveira, M.J.; Carvalho, A.S.; Mendes, N.; Gilmartin, T.; Head, S.R.; Figueiredo, C.; David, L.; Santos-Silva, F.; Reis, C.A.
    Helicobacter pylori induces beta 3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x (2008), J. Clin. Invest., 118, 2325-2336.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.1.206 medicine adhesion of Helicobacter pylori to epithelial cells is mediated by bacterial adhesins that bind carbohydrate ligands expressed by the epithelial gastric cells, bea3GnT5 transferase induction is specific to infection with highly pathogenic strains Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.206 expression in Escherichia coli, overexpression of beta3GnT5 in MNK-45 cells and AGS cells, transfection with lipofectamine Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.206 Homo sapiens
-
 patients with chronic Helicobacter pylori infection
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.206 AGS cell
-
 Homo sapiens
-
2.4.1.206 MKN-45 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.206 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1-4)-beta-D-glucosyl-(1-1)-ceramide
-
 Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.206 beta3GnT5
-
 Homo sapiens
2.4.1.206 GlcNAc transferase
-
 Homo sapiens