EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.15.6 | gene CYP11A1, DNA and amino acid sequence determination of wild-type and mutant enzymes, expression in HeLa cells and COS-1 cells, functional studies of P450scc RNA splicing | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.14.15.6 | c835delA | a naturally occuring CYP11A1 frameshift mutation, heterozygous mutant, phenotype, overview | Homo sapiens |
1.14.15.6 | L141W | a naturally occuring CYP11A1 missense mutation, heterozygous mutant, phenotype, overview | Homo sapiens |
1.14.15.6 | additional information | mutation of CYP11A1 leads to individuals with 46,XY disorders of sex development and primary adrenal failure, identification of P450scc mutations in children, analysis of genotype/phenotype correlations, overview | Homo sapiens |
1.14.15.6 | V415E | a naturally occuring CYP11A1 missense mutation, heterozygous mutant, phenotype, overview | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.15.6 | mitochondrion | - |
Homo sapiens | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.15.6 | Fe2+ | a cytochrome P450 enzyme | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.15.6 | cholesterol + reduced adrenal ferredoxin + O2 | Homo sapiens | - |
pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.15.6 | Homo sapiens | P05108 | gene CYP11A1 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.15.6 | cholesterol + reduced adrenal ferredoxin + O2 | - |
Homo sapiens | pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.15.6 | cholesterol side chain cleavage enzyme | - |
Homo sapiens |
1.14.15.6 | cytochrome P450scc | - |
Homo sapiens |
1.14.15.6 | P450scc | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.15.6 | cytochrome P450 | - |
Homo sapiens | |
1.14.15.6 | reduced adrenal ferredoxin | - |
Homo sapiens |