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Literature summary extracted from

  • Roy, M.; Leclerc, D.; Wu, Q.; Gupta, S.; Kruger, W.D.; Rozen, R.
    Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency (2008), J. Cell. Biochem., 105, 467-476.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.5.1.20 Valproic acid 300 mg/kg treatment increases MTHFR promoter activity 2.5fold and MTHFR mRNA and protein 3.7fold Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.20 expressed in HepG2 cells Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.20 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.20 5,10-methylenetetrahydrofolate + reduced acceptor
-
 Mus musculus 5-methyltetrahydrofolate + oxidized acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.20 methylenetetrahydrofolate reductase
-
 Mus musculus
1.5.1.20 MTHFR
-
 Mus musculus