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Literature summary extracted from

  • Leclerc, D.; Rozen, R.
    Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer (2008), J. Biol. Chem., 283, 3151-3160.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.5.1.20 A23187 treatment of cells results in increase in enzyme mRNA and protein Mus musculus
1.5.1.20 homocysteine treatment of cells results in increase in enzyme mRNA and protein Mus musculus
1.5.1.20 inositol-requiring enzyme-1 the induction of MTHFR was also observed after overexpression of inositol-requiring enzyme-1 Mus musculus
1.5.1.20 additional information transfection of c-Jun and two activators of c-Jun (LiCl and sodium valproate) increase MTHFR expression, MTHFR mRNA is up-regulated by endoplasmic reticulum stress Mus musculus
1.5.1.20 additional information induction of MTHFR is observed after overexpression of inositol-requiring enzyme IRE1 and is inhibited by a dominant-negative mutant of IRE1. Tranfection of c-Jun and its activators LiCl and sodium valproate increase MTHFR expression, whereas inhibitor of c-Jun SP600125 reduces activation Mus musculus
1.5.1.20 thapsigargin treatment of cells results in increase in enzyme mRNA and protein Mus musculus
1.5.1.20 tunicamycin treatment of cells results in increase in enzyme mRNA and protein Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.20 expressed in Escherichia coli and Neuro-2a cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.20 additional information inhibited by a dominant-negative mutant of inositol-requiring enzyme-1, a reported inhibitor of c-Jun (SP600125) and a dominant-negative derivative of c-Jun N-terminal kinase-1 reduce MTHFR activation Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.20 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.20 Neuro-2a cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.20 5,10-methylenetetrahydrofolate + reduced acceptor
-
 Mus musculus 5-methyltetrahydrofolate + oxidized acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.20 methylenetetrahydrofolate reductase
-
 Mus musculus
1.5.1.20 MTHFR
-
 Mus musculus