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Literature summary extracted from

  • Freundlich, J.S.; Wang, F.; Tsai, H.C.; Kuo, M.; Shieh, H.M.; Anderson, J.W.; Nkrumah, L.J.; Valderramos, J.C.; Yu, M.; Kumar, T.R.; Valderramos, S.G.; Jacobs, W.R.; Schiehser, G.A.; Jacobus, D.P.; Fidock, D.A.; Sacchettini, J.C.
    X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy (2007), J. Biol. Chem., 282, 25436-25444.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.9 manganese(III) diphosphate activated through oxidation by manganese(III) diphosphate Plasmodium falciparum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.9 in complex with isoniazid and NAD+, hanging drop vapour diffusion method in 2.4 M (NH4)2SO4, 0.1 M MES pH 5.6, at 16°C Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 2-(2,4-dichlorophenoxy)-5-(2-ethylbutyl)phenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-(2H-tetrazol-5-yl)phenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-(pyridin-2-ylmethyl)phenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-(pyridin-3-ylmethyl)phenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-ethylphenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-methylphenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-propylphenol
-
 Plasmodium falciparum
1.3.1.9 2-(2,4-dichlorophenoxy)-5-pyridin-3-ylphenol
-
 Plasmodium falciparum
1.3.1.9 3-chloro-4-(2-hydroxy-4-pyridin-2-ylphenoxy)benzonitrile
-
 Plasmodium falciparum
1.3.1.9 3-chloro-4-(2-hydroxy-4-pyridin-4-ylphenoxy)benzonitrile
-
 Plasmodium falciparum
1.3.1.9 3-chloro-4-[(3-hydroxy-2'-methylbiphenyl-4-yl)oxy]benzonitrile
-
 Plasmodium falciparum
1.3.1.9 3-chloro-4-[2-hydroxy-4-(pyridin-4-ylmethyl)phenoxy]benzonitrile
-
 Plasmodium falciparum
1.3.1.9 4-(2,4-dichlorophenoxy)-2'-methylbiphenyl-3-ol
-
 Plasmodium falciparum
1.3.1.9 4-(2,4-dichlorophenoxy)-3'-methylbiphenyl-3-ol
-
 Plasmodium falciparum
1.3.1.9 4-(2,4-dichlorophenoxy)-3-hydroxybenzamide
-
 Plasmodium falciparum
1.3.1.9 4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid
-
 Plasmodium falciparum
1.3.1.9 4-(2,4-dichlorophenoxy)-3-hydroxybenzonitrile
-
 Plasmodium falciparum
1.3.1.9 4-(2,4-dichlorophenoxy)-4'-fluorobiphenyl-3-ol
-
 Plasmodium falciparum
1.3.1.9 4-(2,4-dichlorophenoxy)-4'-methylbiphenyl-3-ol
-
 Plasmodium falciparum
1.3.1.9 4-(2,4-dichlorophenoxy)biphenyl-3-ol
-
 Plasmodium falciparum
1.3.1.9 5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
-
 Plasmodium falciparum
1.3.1.9 5-benzyl-2-(2,4-dichlorophenoxy)phenol
-
 Plasmodium falciparum
1.3.1.9 5-butyl-2-(2,4-dichlorophenoxy)phenol
-
 Plasmodium falciparum
1.3.1.9 isoniazid
-
 Plasmodium falciparum
1.3.1.9 triclosan uncompetitive inhibitor Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Plasmodium falciparum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.9
-
 Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 crotonyl-CoA + NADH + H+
-
 Plasmodium falciparum butyryl-CoA + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 enoyl acyl carrier protein reductase
-
 Plasmodium falciparum
1.3.1.9 ENR
-
 Plasmodium falciparum
1.3.1.9 InhA
-
 Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 NADH
-
 Plasmodium falciparum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.9 0.000038
-
-
 Plasmodium falciparum 4-(2,4-dichlorophenoxy)-4'-fluorobiphenyl-3-ol
1.3.1.9 0.000049
-
-
 Plasmodium falciparum 4-(2,4-dichlorophenoxy)-3-hydroxybenzonitrile
1.3.1.9 0.000071
-
-
 Plasmodium falciparum 5-benzyl-2-(2,4-dichlorophenoxy)phenol
1.3.1.9 0.000073
-
-
 Plasmodium falciparum triclosan
1.3.1.9 0.000076
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
1.3.1.9 0.00011
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-ethylphenol
1.3.1.9 0.00012
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-(2-ethylbutyl)phenol
1.3.1.9 0.00014
-
-
 Plasmodium falciparum 4-(2,4-dichlorophenoxy)biphenyl-3-ol
1.3.1.9 0.00018
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
1.3.1.9 0.00019
-
-
 Plasmodium falciparum 4-(2,4-dichlorophenoxy)-4'-methylbiphenyl-3-ol
1.3.1.9 0.0002
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-methylphenol
1.3.1.9 0.00021
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-propylphenol
1.3.1.9 0.00023
-
-
 Plasmodium falciparum 4-(2,4-dichlorophenoxy)-3'-methylbiphenyl-3-ol
1.3.1.9 0.00029
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
1.3.1.9 0.00041
-
-
 Plasmodium falciparum 3-chloro-4-[(3-hydroxy-2'-methylbiphenyl-4-yl)oxy]benzonitrile
1.3.1.9 0.00044
-
-
 Plasmodium falciparum 4-(2,4-dichlorophenoxy)-2'-methylbiphenyl-3-ol
1.3.1.9 0.00044
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
1.3.1.9 0.00048
-
-
 Plasmodium falciparum 5-butyl-2-(2,4-dichlorophenoxy)phenol
1.3.1.9 0.00053
-
-
 Plasmodium falciparum 3-chloro-4-[2-hydroxy-4-(pyridin-4-ylmethyl)phenoxy]benzonitrile
1.3.1.9 0.00053
-
-
 Plasmodium falciparum 5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
1.3.1.9 0.00064
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-(pyridin-2-ylmethyl)phenol
1.3.1.9 0.0007
-
-
 Plasmodium falciparum 3-chloro-4-(2-hydroxy-4-pyridin-2-ylphenoxy)benzonitrile
1.3.1.9 0.00084
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-(pyridin-3-ylmethyl)phenol
1.3.1.9 0.0028
-
-
 Plasmodium falciparum 3-chloro-4-(2-hydroxy-4-pyridin-4-ylphenoxy)benzonitrile
1.3.1.9 0.021
-
-
 Plasmodium falciparum 4-(2,4-dichlorophenoxy)-3-hydroxybenzamide
1.3.1.9 0.033
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-pyridin-3-ylphenol
1.3.1.9 0.1
-
-
 Plasmodium falciparum 4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid
1.3.1.9 0.1
-
-
 Plasmodium falciparum 2-(2,4-dichlorophenoxy)-5-(2H-tetrazol-5-yl)phenol