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Literature summary extracted from

  • Chan, G.; Hardej, D.; Santoro, M.; Lau-Cam, C.; Billack, B.
    Evaluation of the antimicrobial activity of ebselen: role of the yeast plasma membrane H+-ATPase (2007), J. Biochem. Mol. Toxicol., 21, 252-264.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.2.1 2-phenyl-1,2-benzisoselenazol-3(2H)-one i.e. ebselen, inhibition of enzyme results in inhibition of medium acidification. Fungicidal effect is at least in part due to interference with both the proton-translocating function and the ATPase activity of plasma membrane H+-ATPase Bacillus subtilis
7.1.2.1 2-phenyl-1,2-benzisoselenazol-3(2H)-one i.e. ebselen, inhibition of enzyme results in inhibition of medium acidification. Fungicidal effect is at least in part due to interference with both the proton-translocating function and the ATPase activity of plasma membrane H+-ATPase Micrococcus luteus
7.1.2.1 2-phenyl-1,2-benzisoselenazol-3(2H)-one i.e. ebselen, inhibition of enzyme results in inhibition of medium acidification. Fungicidal effect is at least in part due to interference with both the proton-translocating function and the ATPase activity of plasma membrane H+-ATPase Saccharomyces cerevisiae
7.1.2.1 2-phenyl-1,2-benzisoselenazol-3(2H)-one i.e. ebselen, inhibition of enzyme results in inhibition of medium acidification. Fungicidal effect is at least in part due to interference with both the proton-translocating function and the ATPase activity of plasma membrane H+-ATPase Staphylococcus aureus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
7.1.2.1 Bacillus subtilis
-
-
-
7.1.2.1 Micrococcus luteus
-
-
-
7.1.2.1 Saccharomyces cerevisiae
-
-
-
7.1.2.1 Staphylococcus aureus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining