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Literature summary extracted from

  • Sen, G.; Mukhopadhyay, S.; Ray, M.; Biswas, T.
    Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity (2008), J. Antimicrob. Chemother., 61, 1066-1075.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.17.4.1 additional information the enzyme is a target for drug design against the parasite Leishmania donovani

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 quercetin i.e. 3,3',4',5,7-pentahydroxyflavone, isolated from air-dried powdered leaves of Vitex negundo, a lipophilic metal chelator, that interferes with the parasite's iron metabolism inhibiting Fe2+ acquisition from an endogenous source, combination of quercetin with serum albumin increases its bioavailability, the inhibitor causes deprivation of the enzyme of iron which in turn destabilized the critical tyrosyl radical required for its catalysing activity Leishmania donovani

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.4.1 Fe2+
-
 Leishmania donovani

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.1 CDP + thioredoxin Leishmania donovani
-
 2'-deoxyCDP + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 CDP + thioredoxin Leishmania donovani MHOM/IN/1983/AG83
-
 2'-deoxyCDP + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 ribonucleoside diphosphate + thioredoxin Leishmania donovani the enzyme catalyses the rate-limiting step of DNA synthesis in the pathogen 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 ribonucleoside diphosphate + thioredoxin Leishmania donovani MHOM/IN/1983/AG83 the enzyme catalyses the rate-limiting step of DNA synthesis in the pathogen 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Leishmania donovani
-
-
-
1.17.4.1 Leishmania donovani MHOM/IN/1983/AG83
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.1 amastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 CDP + thioredoxin
-
 Leishmania donovani 2'-deoxyCDP + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 CDP + thioredoxin
-
 Leishmania donovani MHOM/IN/1983/AG83 2'-deoxyCDP + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 ribonucleoside diphosphate + thioredoxin the enzyme catalyses the rate-limiting step of DNA synthesis in the pathogen Leishmania donovani 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 ribonucleoside diphosphate + thioredoxin classical pathway via tyrosyl radical Leishmania donovani 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 ribonucleoside diphosphate + thioredoxin the enzyme catalyses the rate-limiting step of DNA synthesis in the pathogen Leishmania donovani MHOM/IN/1983/AG83 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 ribonucleoside diphosphate + thioredoxin classical pathway via tyrosyl radical Leishmania donovani MHOM/IN/1983/AG83 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.4.1 thioredoxin
-
 Leishmania donovani