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Literature summary extracted from

  • Lommel, M.; Willer, T.; Strahl, S.
    POMT2, a key enzyme in Walker-Warburg syndrome: somatic sPOMT2, but not testis-specific tPOMT2, is crucial for mannosyltransferase activity in vivo (2008), Glycobiology, 18, 615-625.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.109 Bos taurus
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2.4.1.109 Canis lupus familiaris
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2.4.1.109 Equus caballus
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2.4.1.109 Felis catus
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2.4.1.109 Mus musculus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.109 embryo sPomt2, but not tPomt2, is prominently expressed in mouse embryos in the tissues that are most severely affected in Walker-Warburg syndrome (developing muscle, eye, and brain) Mus musculus
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2.4.1.109 germ cell tPOMT2 is restricted to the acrosome of male germ cells and is not involved in the biosynthesis of O-mannosyl glycans in vivo. tPOMT2 is highly conserved among mammals, including humans, suggesting a crucial function that is distinct from sPOMT2 Mus musculus
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2.4.1.109 testis in testis both POMT2 isoforms are stably expressed. In contrast to tPOMT2, which is restricted to developing spermatogenic cells, sPOMT2 is present in nonspermatogenic cells. sPOMT2–POMT1 complexes catalyze mannosyltransfer in adult somatic tissues and testis Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.109 POMT2
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 Bos taurus
2.4.1.109 POMT2
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 Canis lupus familiaris
2.4.1.109 POMT2
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 Felis catus
2.4.1.109 POMT2
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 Equus caballus
2.4.1.109 protein mannosyltransferase
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 Mus musculus
2.4.1.109 sPOMT2
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 Mus musculus
2.4.1.109 tPOmt2
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 Mus musculus