EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.99.29 | - |
Homo sapiens |
1.14.99.29 | - |
Saccharomyces cerevisiae |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.99.29 | eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2 | Homo sapiens | - |
eukaryotic translation initiation factor eIF-5A hypusine + H2O + A | - |
? | |
1.14.99.29 | eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2 | Saccharomyces cerevisiae | - |
eukaryotic translation initiation factor eIF-5A hypusine + H2O + A | - |
? | |
1.14.99.29 | additional information | Saccharomyces cerevisiae | following mutants of human eIF-5A are substrates for DOHH - K47A, K47R, G49A, G52A, K55A, P74A, L91A and L101A | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.99.29 | Homo sapiens | - |
- |
- |
1.14.99.29 | Saccharomyces cerevisiae | - |
- |
- |
2.5.1.46 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.99.29 | - |
Homo sapiens |
1.14.99.29 | - |
Saccharomyces cerevisiae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.99.29 | eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2 | - |
Homo sapiens | eukaryotic translation initiation factor eIF-5A hypusine + H2O + A | - |
? | |
1.14.99.29 | eukaryotic translation initiation factor eIF-5A deoxyhypusine + O2 + AH2 | - |
Saccharomyces cerevisiae | eukaryotic translation initiation factor eIF-5A hypusine + H2O + A | - |
? | |
1.14.99.29 | additional information | following mutants of human eIF-5A are substrates for DOHH - K47A, K47R, G49A, G52A, K55A, P74A, L91A and L101A | Saccharomyces cerevisiae | ? | - |
? | |
2.5.1.46 | additional information | mutants of substrate [eIF5A-1-precursor]-lysine with changes in residue K50, and mutants G52A and K55A are no substrates. The hypusine site loop has critical importance in eIF5A function and hypusine modification | Saccharomyces cerevisiae | ? | - |
? | |
2.5.1.46 | [eIF5A-1-precursor]-lysine + spermidine | - |
Saccharomyces cerevisiae | [eIF5A-1-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.99.29 | deoxyhypusine hydroxylase | - |
Homo sapiens |
1.14.99.29 | deoxyhypusine hydroxylase | - |
Saccharomyces cerevisiae |
1.14.99.29 | DOHH | - |
Homo sapiens |
1.14.99.29 | hDOHH | - |
Saccharomyces cerevisiae |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.99.29 | 37 | - |
combined deoxyhypusine synthase and hydroxylase assay | Homo sapiens |
1.14.99.29 | 37 | - |
combined deoxyhypusine synthase and hydroxylase assay | Saccharomyces cerevisiae |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.14.99.29 | 8.5 | - |
combined deoxyhypusine synthase and hydroxylase assay | Homo sapiens |
1.14.99.29 | 8.5 | - |
combined deoxyhypusine synthase and hydroxylase assay | Saccharomyces cerevisiae |