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Literature summary extracted from

  • Vernace, V.A.; Arnaud, L.; Schmidt-Glenewinkel, T.; Figueiredo-Pereira, M.E.
    Aging perturbs 26S proteasome assembly in Drosophila melanogaster (2007), FASEB J., 21, 2672-2682.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.6.1.5 medicine the finding that the disassembly of the 26S proteasome is an old-age event could explain the presence of protein deposits containing ubiquitinated proteins and oxidatively modified proteins in nonpathologic aging, as well as in a variety of aging-related neurodegenerative disorders Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.1.5 additional information a decline in proteasome activity with the aging process is shown Drosophila melanogaster
5.6.1.5 PSI proteasome inhibitor Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.5 ATP + H2O + polypeptide Drosophila melanogaster
-
 ADP + phosphate + unfolded polypeptide
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.5 Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.5 ATP + H2O + polypeptide
-
 Drosophila melanogaster ADP + phosphate + unfolded polypeptide
-
 ir

Synonyms

EC Number Synonyms Comment Organism
5.6.1.5 26S proteasome
-
 Drosophila melanogaster
5.6.1.5 proteasome ATPase
-
 Drosophila melanogaster

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.6.1.5 37
-
 in-gel proteasome activity assay Drosophila melanogaster

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6.1.5 7.4
-
 in-gel proteasome activity assay Drosophila melanogaster