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Literature summary extracted from

  • Rajtar, S.; Irman-Florjanc, T.
    Amitriptyline affects histamine-N-methyltransferase and diamine oxidase activity in rats and guinea pigs (2007), Eur. J. Pharmacol., 574, 201-208.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.22 Cavia porcellus
-
-
-
1.4.3.22 Rattus norvegicus
-
-
-
2.1.1.8 Cavia porcellus
-
-
-
2.1.1.8 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.22 blood plasma amitriptyline at 0.03, 0.05, 0.1 and 0.5 mM concentrations lower enzyme activity in the plasma of the heparinised rat by 14, 22, 23 and 28%, respectively Rattus norvegicus
-
1.4.3.22 blood plasma in vitro treatment with 100 nM, 0.05, 0.1 and 0.5 mM amitriptyline increases the guinea pig plasma diamine oxidase activity by 5, 7, 17 and 11%, respectively Cavia porcellus
-
2.1.1.8 cerebrum
-
 Cavia porcellus
-
2.1.1.8 kidney
-
 Cavia porcellus
-
2.1.1.8 kidney
-
 Rattus norvegicus
-
2.1.1.8 large intestine
-
 Cavia porcellus
-
2.1.1.8 lung RNA expression is amplified after treatment with amitriptyline Cavia porcellus
-
2.1.1.8 small intestine
-
 Cavia porcellus
-
2.1.1.8 spleen
-
 Rattus norvegicus
-
2.1.1.8 spleen RNA expression is amplified after treatment with amitriptyline Cavia porcellus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.8 additional information
-
 enzyme activities are increased in spleen and kidney of amitriptyline treated rats Rattus norvegicus
2.1.1.8 additional information
-
 enzyme activities are increased in tissues of amitriptyline treated guinea pigs Cavia porcellus
2.1.1.8 0.000022
-
 large intestine, saline treated Cavia porcellus
2.1.1.8 0.000028
-
 large intestine, amitriptyline treated Cavia porcellus
2.1.1.8 0.000036
-
 kidney, saline treated Cavia porcellus
2.1.1.8 0.000038
-
 lung, saline treated Cavia porcellus
2.1.1.8 0.000052
-
 lung, amitriptyline treated Cavia porcellus
2.1.1.8 0.000054
-
 kidney, amitriptyline treated Cavia porcellus
2.1.1.8 0.00008
-
 cerebrum, saline treated Cavia porcellus
2.1.1.8 0.000101
-
 small intestine, saline treated Cavia porcellus
2.1.1.8 0.000121
-
 cerebrum, amitriptyline treated Cavia porcellus
2.1.1.8 0.000132
-
 spleen, saline treated Cavia porcellus
2.1.1.8 0.000163
-
 small intestine, amitriptyline treated Cavia porcellus
2.1.1.8 0.000165
-
 spleen, amitriptyline treated Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Cavia porcellus S-adenosyl-L-homocysteine + N-methylhistamine
-
 ?
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + N-methylhistamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.8 histamine N-methyltransferase
-
 Cavia porcellus
2.1.1.8 histamine N-methyltransferase
-
 Rattus norvegicus
2.1.1.8 HNMT
-
 Cavia porcellus
2.1.1.8 HNMT
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.8 37
-
 assay at Cavia porcellus
2.1.1.8 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.8 7.5
-
 assay Cavia porcellus
2.1.1.8 7.5
-
 assay Rattus norvegicus