Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fujii, T.; Ohira, Y.; Itomi, Y.; Takahashi, Y.; Asano, S.; Morii, M.; Takeguchi, N.; Sakai, H.
    Inhibition of P-type ATPases by [(dihydroindenyl)oxy]acetic acid (DIOA), a K+ -Cl- cotransporter inhibitor (2007), Eur. J. Pharmacol., 560, 123-126.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.2.2.3 pharmacology lower concentration of [(dihydroindenyl)oxy]acetic acid should be used for evaluation of the activity of K+-Cl- cotranporter without affecting the activities of coexisting Na+,K+-ATPase and H+,K+-ATPase in cells Sus scrofa
7.2.2.3 pharmacology lower concentration of [(dihydroindenyl)oxy]acetic acid should be used for evaluation of the activity of K+-Cl- cotranporter without affecting the activities of coexisting Na+,K+-ATPase and H+,K+-ATPase in cells Canis lupus familiaris
7.2.2.10 pharmacology lower concentration of [(dihydroindenyl)oxy]acetic acid should be used for evaluation of the activity of K+-Cl- cotranporter without affecting the activities of coexisting Na+,K+-ATPase and H+,K+-ATPase in cells Oryctolagus cuniculus
7.2.2.19 pharmacology lower concentration of [(dihydroindenyl)oxy]acetic acid should be used for evaluation of the activity of K+-Cl- cotranporter without affecting the activities of coexisting Na+,K+-ATPase and H+,K+-ATPase in cells Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.3 Ouabain
-
 Canis lupus familiaris
7.2.2.3 Ouabain
-
 Sus scrofa
7.2.2.3 [(dihydroindenyl)oxy]acetic acid DIOA Canis lupus familiaris
7.2.2.3 [(dihydroindenyl)oxy]acetic acid DIOA Sus scrofa
7.2.2.10 [(dihydroindenyl)oxy]acetic acid DIOA Oryctolagus cuniculus
7.2.2.19 [(dihydroindenyl)oxy]acetic acid DIOA Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.3 membrane
-
 Sus scrofa 16020
-
7.2.2.10 microsome a microsomal fraction enriched in the transverse tubular system (T-tubule)/sarcoplasmic reticulum, SR, complex is prepared Oryctolagus cuniculus
-
-
7.2.2.19 membrane gastric vesicles are prepared from mucosa in the fundic region of hog stomaches Sus scrofa 16020
-

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Canis lupus familiaris
-
-
-
7.2.2.3 Sus scrofa
-
-
-
7.2.2.10 Oryctolagus cuniculus
-
-
-
7.2.2.19 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 kidney
-
 Canis lupus familiaris
-
7.2.2.3 LLC-PK1 cell in the membrane of porcine LLC-PK1 cells stably expressing rabbit gastric H+,K+-ATPase, [(dihydroindenyl)oxy]acetic acid inhibits activities of endogenous Na+,K+-ATPase Sus scrofa
-
7.2.2.10 muscle back and leg muscles Oryctolagus cuniculus
-
7.2.2.19 gastric mucosa
-
 Sus scrofa
-
7.2.2.19 LLC-PK1 cell LLC-PK1 cells stably expressing alpha- and beta subunits of the gatric H+,K+-ATPase Sus scrofa
-

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Na+,K+-ATPase
-
 Sus scrofa
7.2.2.3 Na+,K+-ATPase
-
 Canis lupus familiaris
7.2.2.3 Na+-exporting ATPase
-
 Sus scrofa
7.2.2.3 Na+-exporting ATPase
-
 Canis lupus familiaris
7.2.2.3 P-type ATPase
-
 Sus scrofa
7.2.2.3 P-type ATPase
-
 Canis lupus familiaris
7.2.2.10 Ca2+-ATPase
-
 Oryctolagus cuniculus
7.2.2.19 gastric H+,K+-ATPase
-
 Sus scrofa
7.2.2.19 H+,K+-ATPase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.2.2.3 37
-
 Na+,K+-ATPase activity assay Sus scrofa
7.2.2.3 37
-
 Na+,K+-ATPase activity assay Canis lupus familiaris
7.2.2.10 37
-
 Ca2+-ATPase activity assay Oryctolagus cuniculus
7.2.2.19 37
-
 H+,K+-ATPase activity assay Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.3 7.4
-
 Na+,K+-ATPase activity assay Sus scrofa
7.2.2.3 7.4
-
 Na+,K+-ATPase activity assay Canis lupus familiaris
7.2.2.10 7
-
 Ca2+-ATPase activity assay Oryctolagus cuniculus
7.2.2.19 6.8
-
 H+,K+-ATPase activity assay Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.2.2.3 0.053
-
-
 Canis lupus familiaris [(dihydroindenyl)oxy]acetic acid
7.2.2.3 0.095
-
 endogenous Na+,K+-ATPase Sus scrofa [(dihydroindenyl)oxy]acetic acid
7.2.2.10 0.127
-
-
 Oryctolagus cuniculus [(dihydroindenyl)oxy]acetic acid
7.2.2.19 0.097
-
 endogenous Na+,K+-ATPase Sus scrofa [(dihydroindenyl)oxy]acetic acid