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Literature summary extracted from

  • Quash, G.; Fournet, G.; Courvoisier, C.; Martinez, R.M.; Chantepie, J.; Paret, M.J.; Pharaboz, J.; Joly-Pharaboz, M.O.; Gore, J.; Andre, J.; Reichert, U.
    Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture (2008), Eur. J. Med. Chem., 43, 906-916.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 dimethyl ampal thiolester 78% inhibition of isozyme ALDH1 at 0.0075 mM Homo sapiens
1.2.1.3 methyl ampal thiolester 32% inhibition of isozyme ALDH1 at 0.0075 mM Homo sapiens
1.2.1.5 dimethyl ampal thiolester complete inhibition of isozyme ALDH3 at 0.0075 mM Homo sapiens
1.2.1.5 methyl ampal thiolester 78% inhibition of isozyme ALDH3 at 0.0075 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-
1.2.1.5 Homo sapiens P30838
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 DU-145 cell
-
 Homo sapiens
-
1.2.1.3 endothelial cell
-
 Homo sapiens
-
1.2.1.3 HPENC cell
-
 Homo sapiens
-
1.2.1.3 prostate cancer cell
-
 Homo sapiens
-
1.2.1.3 prostate gland
-
 Homo sapiens
-
1.2.1.5 DU-145 cell
-
 Homo sapiens
-
1.2.1.5 HPENC cell
-
 Homo sapiens
-
1.2.1.5 prostate cancer cell
-
 Homo sapiens
-
1.2.1.5 prostate gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 acetaldehyde + NAD+ + H2O
-
 Homo sapiens acetate + NADH + H+
-
 ?
1.2.1.5 benzaldehyde + NADP+ + H2O
-
 Homo sapiens benzoate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 ALDH1 isozyme Homo sapiens
1.2.1.5 ALDH3 isozyme Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens
1.2.1.5 NADP+
-
 Homo sapiens