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Literature summary extracted from

  • van Kuilenburg, A.B.; Klumpen, H.; Westermann, A.M.; Zoetekouw, L.; Van Lenthe, H.; Bakker, P.J.; Richel, D.J.; Guchelaar, H.
    Increased dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil and leucovorin (2007), Eur. J. Cancer, 43, 459-465.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.1 leucovorin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.1 buccal mucosa
-
 Homo sapiens
-
1.3.1.1 peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.1 5-fluorouracil + NADH + H+
-
 Homo sapiens 5-fluoro-5,6-dihydrouracil + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.1 dihydropyrimidine dehydrogenase
-
 Homo sapiens
1.3.1.1 DPD
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.1 NAD+
-
 Homo sapiens