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Literature summary extracted from

  • Maguire, M.E.
    The structure of CorA: a Mg(2+)-selective channel (2006), Curr. Opin. Struct. Biol., 16, 432-438.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
7.2.2.14 crystal structure analysis, X-ray structure determination at 3.9 A resolution, PDB ID 2BBJ, overview Thermotoga maritima

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.14 membrane the CorA monomer has a C-terminal membrane domain containing two transmembrane segments Thermotoga maritima 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.14 ATP + H2O + Mg2+/out Thermotoga maritima
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 ADP + phosphate + Mg2+/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.14 Thermotoga maritima
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 gene corA
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.14 ATP + H2O + Mg2+/out
-
 Thermotoga maritima ADP + phosphate + Mg2+/in
-
 ?
7.2.2.14 ATP + H2O + Mg2+/out a fully hydrated Mg2+ binds in the periplasm, interaction of CprA with Mg2+ and transport mechanism, overview Thermotoga maritima ADP + phosphate + Mg2+/in
-
 ?
7.2.2.14 additional information the CorA monomer has a C-terminal membrane domain containing two transmembrane segments, and a large, highly negatively charged N-terminal cytoplasmic soluble domain, the enzyme forms a homopentamer shaped like a funnel with Asn314 at the entrance, which interacts with the ring of positive charges external to the ion conduction pathwayat the cytosolicmembrane interface, in the membrane Thermotoga maritima ?
-
 ?

Subunits

EC Number Subunits Comment Organism
7.2.2.14 pentamer the CorA monomer has a C-terminal membrane domain containing two transmembrane segments, and a large, highly negatively charged N-terminal cytoplasmic soluble domain, the enzyme forms a homopentamer shaped like a funnel, which interacts with the ring of positive charges external to the ion conduction pathway at the cytosolic membrane interface, in the membrane Thermotoga maritima

Synonyms

EC Number Synonyms Comment Organism
7.2.2.14 CorA
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 Thermotoga maritima
7.2.2.14 More the enzyme belongs to the CorA Mg2+ transporter superfamily Thermotoga maritima