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Literature summary extracted from

  • Liskay, R.M.; Wheeler, L.J.; Mathews, C.K.; Erdeniz, N.
    Involvement of deoxycytidylate deaminase in the response to Sn1-type methylation DNA damage in budding yeast (2007), Curr. Biol., 17, R755-R757.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.5.4.12 additional information construction of a dcd1DELTA enzyme-deficient strain, the deletion strain and the dcd1-S178F mutant strain are crossed with a rad52DELTA mgt1DELTA strain and haploid, double and triple mutant strains are generated, rad52DELTA mgt1DELTA dcd1-S178F and rad52DELTA mgt1DELTA dcd1DELTA strains show an increased level of MNNG resistance, while the only dcd1-deficient strain does not, overview, DCD1 deficiency in yeast results in elevation of dCTP pools and a slight decrease in dTTP pools and reduced the frequency of spontaneous and MNNGinduced G/C to A/T mutations, phenotypes, overview Saccharomyces cerevisiae
3.5.4.12 S178F site-directed mutagenesis, the mutation is responsible for MNNG resistance in the drm1-1 strain, Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.12 dCMP + H2O Saccharomyces cerevisiae
-
dUMP + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.12 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.12 dCMP + H2O
-
Saccharomyces cerevisiae dUMP + NH3
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.12 DCD1
-
Saccharomyces cerevisiae
3.5.4.12 deoxycytidylate deaminase
-
Saccharomyces cerevisiae