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Literature summary extracted from

  • Reljic, A.; Simundic, A.M.; Topic, E.; Nikolac, N.; Justinic, D.; Stefanovic, M.
    The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study (2007), Clin. Biochem., 40, 981-985.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.5.1.20 additional information the C677T gene polymorphism decreases enzyme activity and does not significantly contribute to the inherited genetic susceptibility to breast and prostate cancer, while there is some evidence for possible genetic contribution of this polymorphism to the development of head and neck carcinoma Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.20 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.20 blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.20 5,10-methylenetetrahydrofolate + reduced acceptor
-
 Homo sapiens 5-methyltetrahydrofolate + oxidized acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.20 methylenetetrahydrofolate reductase
-
 Homo sapiens
1.5.1.20 MTHFR
-
 Homo sapiens