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Literature summary extracted from

  • Westin, M.A.; Hunt, M.C.; Alexson, S.E.
    Short- and medium-chain carnitine acyltransferases and acyl-CoA thioesterases in mouse provide complementary systems for transport of beta-oxidation products out of peroxisomes (2008), Cell. Mol. Life Sci., 65, 982-990.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.7 mitochondrion the majority of Crat mRNA in mouse is mitochondrial, with only about 1–20% of Crat mRNA being peroxisomal, except for liver, where peroxisomal Crat represents about 38%of total Crat mRNA Mus musculus 5739
-
2.3.1.7 peroxisome the majority of Crat mRNA in mouse is mitochondrial, with only about 1–20% of Crat mRNA being peroxisomal, except for liver, where peroxisomal Crat represents about 38%of total Crat mRNA Mus musculus 5777
-
2.3.1.137 mitochondrion
-
 Mus musculus 5739
-
2.3.1.137 mitochondrion the crat gene contains 2 alternative start codons, translation from the first codon results in a protein of 626 amino acids, with a 21-amino acid leader sequence that targets the CRAT protein to mitochondria Mus musculus 5739
-
2.3.1.137 peroxisome
-
 Mus musculus 5777
-
2.3.1.137 peroxisome in the peroxisomal CRAT mRNA, there is an in-frame stop codon and translation starts at a downstream second start codon, resulting in a protein that contains 605 amino acids Mus musculus 5777
-
3.1.2.18 peroxisome
-
 Mus musculus 5777
-
3.1.2.20 peroxisome
-
 Mus musculus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.137 acetyl-CoA + L-carnitine Mus musculus
-
 CoA + acetyl-carnitine
-
 ?
2.3.1.137 acetyl-CoA + L-carnitine Mus musculus 129/Sv
-
 CoA + acetyl-carnitine
-
 ?
2.3.1.137 additional information Mus musculus peroxisomal carnitine acyltransferases and acyl-CoA thioesterases are differently expressed to function as complementary enzymes for transport of beta-oxidation metabolites ?
-
 ?
2.3.1.137 additional information Mus musculus peroxisomes contain carnitine acetyltransferase and octanoyltransferase that produce carnitine ester for transport out of the peroxisomes ?
-
 ?
2.3.1.137 additional information Mus musculus 129/Sv peroxisomal carnitine acyltransferases and acyl-CoA thioesterases are differently expressed to function as complementary enzymes for transport of beta-oxidation metabolites ?
-
 ?
2.3.1.137 additional information Mus musculus 129/Sv peroxisomes contain carnitine acetyltransferase and octanoyltransferase that produce carnitine ester for transport out of the peroxisomes ?
-
 ?
2.3.1.137 octanoyl-CoA + L-carnitine Mus musculus
-
 CoA + L-octanoylcarnitine
-
 ?
2.3.1.137 octanoyl-CoA + L-carnitine Mus musculus 129/Sv
-
 CoA + L-octanoylcarnitine
-
 ?
2.3.1.137 propionyl-CoA + L-carnitine Mus musculus
-
 CoA + propionyl-carnitine
-
 ?
2.3.1.137 propionyl-CoA + L-carnitine Mus musculus 129/Sv
-
 CoA + propionyl-carnitine
-
 ?
3.1.2.18 an acyl-CoA + H2O Mus musculus
-
 CoA + a carboxylate
-
 ?
3.1.2.18 additional information Mus musculus acyl-CoA thioesterase produces free fatty acids ?
-
 ?
3.1.2.18 additional information Mus musculus peroxisomal carnitine acyl-CoA thioesterases and acyltransferases are differently expressed to function as complementary enzymes for transport of beta-oxidation metabolites ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Mus musculus
-
 Sv/129 mice
-
2.3.1.7 Mus musculus 129/Sv
-
 Sv/129 mice
-
2.3.1.137 Mus musculus
-
-
-
2.3.1.137 Mus musculus
-
 male Sv/129 mice
-
2.3.1.137 Mus musculus 129/Sv
-
-
-
3.1.2.18 Mus musculus
-
 male Sv/129 mice
-
3.1.2.20 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.7 brown adipose tissue
-
 Mus musculus
-
2.3.1.7 heart Crat is most highly expressed in heart, brown adipose tissue and white adipose tissue Mus musculus
-
2.3.1.7 liver
-
 Mus musculus
-
2.3.1.7 white adipose tissue
-
 Mus musculus
-
2.3.1.137 brain
-
 Mus musculus
-
2.3.1.137 brown adipose tissue high expression of CRAT Mus musculus
-
2.3.1.137 heart high expression of CRAT Mus musculus
-
2.3.1.137 intestinal epithelium proximal Mus musculus
-
2.3.1.137 intestinal muscle proximal Mus musculus
-
2.3.1.137 intestine proximal and distal Mus musculus
-
2.3.1.137 kidney
-
 Mus musculus
-
2.3.1.137 liver
-
 Mus musculus
-
2.3.1.137 lung
-
 Mus musculus
-
2.3.1.137 additional information low in distal intestine epithelium, distal intestine muscle, brain, heart, lung, spleen, brown and white adipose tissue Mus musculus
-
2.3.1.137 spleen
-
 Mus musculus
-
2.3.1.137 white adipose tissue high expression of CRAT Mus musculus
-
3.1.2.18 brain low expression of Acot12 Mus musculus
-
3.1.2.18 brown adipose tissue low expression of Acot12 Mus musculus
-
3.1.2.18 heart low expression of Acot12 Mus musculus
-
3.1.2.18 intestine proximal, high expression of Acot12 Mus musculus
-
3.1.2.18 kidney high expression of Acot12 Mus musculus
-
3.1.2.18 liver high expression of Acot12 Mus musculus
-
3.1.2.18 lung low expression of Acot12 Mus musculus
-
3.1.2.18 spleen low expression of Acot12 Mus musculus
-
3.1.2.18 white adipose tissue low expression of Acot12 Mus musculus
-
3.1.2.20 intestinal epithelium
-
 Mus musculus
-
3.1.2.20 intestine
-
 Mus musculus
-
3.1.2.20 kidney
-
 Mus musculus
-
3.1.2.20 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.137 acetyl-CoA + L-carnitine
-
 Mus musculus CoA + acetyl-carnitine
-
 ?
2.3.1.137 acetyl-CoA + L-carnitine
-
 Mus musculus 129/Sv CoA + acetyl-carnitine
-
 ?
2.3.1.137 additional information peroxisomal carnitine acyltransferases and acyl-CoA thioesterases are differently expressed to function as complementary enzymes for transport of beta-oxidation metabolites Mus musculus ?
-
 ?
2.3.1.137 additional information peroxisomes contain carnitine acetyltransferase and octanoyltransferase that produce carnitine ester for transport out of the peroxisomes Mus musculus ?
-
 ?
2.3.1.137 additional information peroxisomal carnitine acyltransferases and acyl-CoA thioesterases are differently expressed to function as complementary enzymes for transport of beta-oxidation metabolites Mus musculus 129/Sv ?
-
 ?
2.3.1.137 additional information peroxisomes contain carnitine acetyltransferase and octanoyltransferase that produce carnitine ester for transport out of the peroxisomes Mus musculus 129/Sv ?
-
 ?
2.3.1.137 octanoyl-CoA + L-carnitine
-
 Mus musculus CoA + L-octanoylcarnitine
-
 ?
2.3.1.137 octanoyl-CoA + L-carnitine
-
 Mus musculus 129/Sv CoA + L-octanoylcarnitine
-
 ?
2.3.1.137 propionyl-CoA + L-carnitine
-
 Mus musculus CoA + propionyl-carnitine
-
 ?
2.3.1.137 propionyl-CoA + L-carnitine
-
 Mus musculus 129/Sv CoA + propionyl-carnitine
-
 ?
3.1.2.18 an acyl-CoA + H2O
-
 Mus musculus CoA + a carboxylate
-
 ?
3.1.2.18 additional information acyl-CoA thioesterase produces free fatty acids Mus musculus ?
-
 ?
3.1.2.18 additional information peroxisomal carnitine acyl-CoA thioesterases and acyltransferases are differently expressed to function as complementary enzymes for transport of beta-oxidation metabolites Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.7 carnitine acetyltransferase
-
 Mus musculus
2.3.1.7 CRAT
-
 Mus musculus
2.3.1.137 carnitine acyltransferase
-
 Mus musculus
2.3.1.137 carnitine octanoyltransferase
-
 Mus musculus
2.3.1.137 carnitine octanoyltransferase CROT Mus musculus
2.3.1.137 CRAT
-
 Mus musculus
2.3.1.137 CrOT
-
 Mus musculus
2.3.1.137 medium-chain carnitine acyltransferase
-
 Mus musculus
2.3.1.137 short-chain carnitine acyltransferase
-
 Mus musculus
3.1.2.18 Acot12
-
 Mus musculus
3.1.2.18 Acot15
-
 Mus musculus
3.1.2.18 Acot8
-
 Mus musculus
3.1.2.18 acyl-CoA hydrolase
-
 Mus musculus
3.1.2.18 acyl-CoA thioesterase
-
 Mus musculus
3.1.2.20 acyl-CoA thioesterase Acot12
-
 Mus musculus
3.1.2.20 acyl-CoA thioesterase Acot8
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.2.18 ADP
-
 Mus musculus