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Literature summary extracted from

  • Park, J.; Gupta, R.S.
    Adenosine kinase and ribokinase - the RK family of proteins (2008), Cell. Mol. Life Sci., 65, 2875-2896.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.15 NH4+ activates Escherichia coli
2.7.1.20 inorganic phosphate stimulates Spinacia oleracea
2.7.1.20 inorganic phosphate stimulates Trypanosoma brucei
2.7.1.20 inorganic phosphate stimulates Leishmania donovani
2.7.1.20 inorganic phosphate stimulates Homo sapiens
2.7.1.20 phosphate stimulates Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.15 Cs+ activates Escherichia coli
2.7.1.15 K+ activates Escherichia coli
2.7.1.15 additional information no activity in the absence of divalent metal ions Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.15 additional information no activity in the absence of divalent metal ions Bos taurus
2.7.1.15 additional information no activity in the absence of divalent metal ions Escherichia coli
2.7.1.20 Ca2+ can substitute for Mg2+ Homo sapiens
2.7.1.20 Co2+ can substitute for Mg2+ Homo sapiens
2.7.1.20 Mg2+ required Homo sapiens
2.7.1.20 Mn2+ can substitute for Mg2+ Homo sapiens
2.7.1.20 Ni2+ can substitute for Mg2+ Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.15 Arabidopsis thaliana
-
-
-
2.7.1.15 Bos taurus
-
calf
-
2.7.1.15 Burkholderia cepacia
-
-
-
2.7.1.15 Entamoeba histolytica
-
-
-
2.7.1.15 Escherichia coli P0A9J6
-
-
2.7.1.15 Homo sapiens
-
-
-
2.7.1.15 Leishmania major
-
-
-
2.7.1.15 Saccharomyces cerevisiae
-
-
-
2.7.1.15 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
2.7.1.15 Trypanosoma cruzi
-
-
-
2.7.1.20 Arabidopsis thaliana
-
-
-
2.7.1.20 Caenorhabditis elegans
-
-
-
2.7.1.20 Drosophila melanogaster
-
-
-
2.7.1.20 Homo sapiens P55263
-
-
2.7.1.20 Leishmania donovani
-
-
-
2.7.1.20 Saccharomyces cerevisiae
-
-
-
2.7.1.20 Schizosaccharomyces pombe
-
-
-
2.7.1.20 Spinacia oleracea
-
-
-
2.7.1.20 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.15 ATP + 2-deoxy-D-ribose
-
Salmonella enterica subsp. enterica serovar Typhimurium ADP + 2-deoxy-D-ribose 5-phosphate
-
?
2.7.1.15 ATP + 2-deoxy-D-ribose 31% if the activity with D-ribose Escherichia coli ADP + 2-deoxy-D-ribose 5-phosphate
-
?
2.7.1.15 ATP + 2-deoxy-D-ribose 75% of the activity with D-ribose Bos taurus ADP + 2-deoxy-D-ribose 5-phosphate
-
?
2.7.1.15 ATP + D-arabinose 0.74% if the activity with D-ribose Escherichia coli ADP + D-arabinose 5-phosphate
-
?
2.7.1.15 ATP + D-arabinose 4% if the activity with D-ribose Homo sapiens ADP + D-arabinose 5-phosphate
-
?
2.7.1.15 ATP + D-ribose
-
Salmonella enterica subsp. enterica serovar Typhimurium ADP + D-ribose 5-phosphate
-
?
2.7.1.15 ATP + D-ribose
-
Homo sapiens ADP + D-ribose 5-phosphate
-
?
2.7.1.15 ATP + D-ribose
-
Bos taurus ADP + D-ribose 5-phosphate
-
?
2.7.1.15 ATP + D-ribose
-
Leishmania major ADP + D-ribose 5-phosphate
-
?
2.7.1.15 ATP + D-ribose
-
Escherichia coli ADP + D-ribose 5-phosphate
-
?
2.7.1.15 ATP + D-xylose 1.06% if the activity with D-ribose Escherichia coli ?
-
?
2.7.1.15 additional information GTP displays activity, but at a level which was two orders of magnitude lower versus ATP Escherichia coli ?
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.20 monomer the active form of AK is a monomer, which is composed of an alphabetaalpha sandwich domain and a smaller lid domain Drosophila melanogaster
2.7.1.20 monomer the active form of AK is a monomer, which is composed of an alphabetaalpha sandwich domain and a smaller lid domain Saccharomyces cerevisiae
2.7.1.20 monomer the active form of AK is a monomer, which is composed of an alphabetaalpha sandwich domain and a smaller lid domain Spinacia oleracea
2.7.1.20 monomer the active form of AK is a monomer, which is composed of an alphabetaalpha sandwich domain and a smaller lid domain Trypanosoma brucei
2.7.1.20 monomer the active form of AK is a monomer, which is composed of an alphabetaalpha sandwich domain and a smaller lid domain Schizosaccharomyces pombe
2.7.1.20 monomer the active form of AK is a monomer, which is composed of an alphabetaalpha sandwich domain and a smaller lid domain Leishmania donovani
2.7.1.20 monomer the active form of AK is a monomer, which is composed of an alphabetaalpha sandwich domain and a smaller lid domain Homo sapiens
2.7.1.20 monomer the active form of the enzyme is a monomer, which is composed of an alphabetaalpha sandwich domain and a smaller lid domain Arabidopsis thaliana
2.7.1.20 monomer the active form of the enzyme is a monomer, which is composed of an alphabetaalpha sandwich domain and a smaller lid domain Caenorhabditis elegans