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Literature summary extracted from

  • Rodriguez, C.; Martinez-Gonzalez, J.; Raposo, B.; Alcudia, J.F.; Guadall, A.; Badimon, L.
    Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases (2008), Cardiovasc. Res., 79, 7-13.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.3.13 transforming growth factor beta increases LOX expression and activity Mus musculus

Application

EC Number Application Comment Organism
1.4.3.13 medicine LOX could play a key role in vascular homeostasis and, hence, it emerges as a new player in cardiovascular diseases Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.13 homocysteine
-
 Mus musculus
1.4.3.13 low-density lipoprotein decreases lysyl oxidase mRNA levels in endothelial cells Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.13 Cu2+ dependent Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.13 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.13 cardiovascular system
-
 Mus musculus
-
1.4.3.13 coronary artery
-
 Mus musculus
-
1.4.3.13 endothelium
-
 Mus musculus
-
1.4.3.13 fibroblast
-
 Mus musculus
-
1.4.3.13 vascular smooth muscle cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
 Mus musculus peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.13 LOX
-
 Mus musculus
1.4.3.13 lysyl oxidase
-
 Mus musculus