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Literature summary extracted from

  • Guarcello, V.; Blanquicett, C.; Naguib, F.N.; El Kouni, M.H.
    Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity (2008), Cancer Chemother. Pharmacol., 62, 85-96.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 additional information thymidine phosphorylase promoter methylation is a mechanism for down-regulation of enzyme expression in cancer cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.4 DLD-1 cell
-
 Homo sapiens
-
2.4.2.4 HT-29 cell
-
 Homo sapiens
-
2.4.2.4 MDA-MB-231 cell
-
 Homo sapiens
-
2.4.2.4 RCC 786-O cell
-
 Homo sapiens
-
2.4.2.4 SK-BR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?