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Literature summary extracted from

  • Singh, K.; Bhakuni, V.
    Cation induced differential effect on structural and functional properties of Mycobacterium tuberculosis alpha -isopropylmalate synthase (2007), BMC Struct. Biol., 7, 39.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.13 Cd2+ the ion interacts directly with the catalytic domain of the enzyme and induce unfolding/denaturation of the domain Mycobacterium tuberculosis
2.3.3.13 Zn2+ the ion interacts directly with the catalytic domain of the enzyme and induce unfolding/denaturation of the domain Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.3.13 K+ the activator interacts with the catalytic TIM barrel domain, it does not induce any significant effect on the enzyme structure Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.13 Mycobacterium tuberculosis
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.3.3.13 Alpha-isopropylmalate synthase
-
Mycobacterium tuberculosis
2.3.3.13 MtalphaIPMS
-
Mycobacterium tuberculosis