Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dunsmore, C.J.; Miller, K.; Blake, K.L.; Patching, S.G.; Henderson, P.J.; Garnett, J.A.; Stubbings, W.J.; Phillips, S.E.; Palestrant, D.J.; Angeles, J.D.; Leeds, J.A.; Chopra, I.; Fishwick, C.W.
    2-Aminotetralones: novel inhibitors of MurA and MurZ (2008), Bioorg. Med. Chem. Lett., 18, 1730-1734.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.7 C115D mutant protein is functional and resistant to fosfomycin and inhibitors 2-[4-(2-hydroxyethyl)piperazin-1-yl]-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one and2-(4-methylpiperazin-1-yl)-3,4-dihydronaphthalen-1(2H)-one Staphylococcus aureus
2.5.1.7 C115D mutant protein is functional and resistant to fosfomycin and inhibitors 2-[4-(2-hydroxyethyl)piperazin-1-yl]-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one and2-(4-methylpiperazin-1-yl)-3,4-dihydronaphthalen-1(2H)-one Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.7 2-(4-methylpiperazin-1-yl)-3,4-dihydronaphthalen-1(2H)-one
-
Escherichia coli
2.5.1.7 2-(4-methylpiperazin-1-yl)-3,4-dihydronaphthalen-1(2H)-one
-
Staphylococcus aureus
2.5.1.7 2-[4-(2-hydroxyethyl)piperazin-1-yl]-3,4-dihydronaphthalen-1(2H)-one
-
Escherichia coli
2.5.1.7 2-[4-(2-hydroxyethyl)piperazin-1-yl]-3,4-dihydronaphthalen-1(2H)-one
-
Staphylococcus aureus
2.5.1.7 2-[4-(2-hydroxyethyl)piperazin-1-yl]-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one
-
Escherichia coli
2.5.1.7 2-[4-(2-hydroxyethyl)piperazin-1-yl]-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one
-
Staphylococcus aureus
2.5.1.7 6,7-dimethoxy-2-[4-(2-phenylethyl)piperazin-1-yl]-3,4-dihydronaphthalen-1(2H)-one
-
Escherichia coli
2.5.1.7 6,7-dimethoxy-2-[4-(2-phenylethyl)piperazin-1-yl]-3,4-dihydronaphthalen-1(2H)-one
-
Staphylococcus aureus
2.5.1.7 fosfomycin
-
Escherichia coli
2.5.1.7 fosfomycin
-
Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.7 Escherichia coli P0A749
-
-
2.5.1.7 Staphylococcus aureus
-
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.7 0.00046
-
-
Escherichia coli fosfomycin
2.5.1.7 0.00136
-
-
Staphylococcus aureus fosfomycin
2.5.1.7 0.00313
-
-
Escherichia coli 2-[4-(2-hydroxyethyl)piperazin-1-yl]-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one
2.5.1.7 0.00853
-
-
Escherichia coli 2-(4-methylpiperazin-1-yl)-3,4-dihydronaphthalen-1(2H)-one
2.5.1.7 0.01204
-
-
Staphylococcus aureus 2-(4-methylpiperazin-1-yl)-3,4-dihydronaphthalen-1(2H)-one
2.5.1.7 0.01252
-
-
Staphylococcus aureus 2-[4-(2-hydroxyethyl)piperazin-1-yl]-3,4-dihydronaphthalen-1(2H)-one
2.5.1.7 0.01735
-
-
Staphylococcus aureus 2-[4-(2-hydroxyethyl)piperazin-1-yl]-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one
2.5.1.7 0.02249
-
-
Escherichia coli 2-[4-(2-hydroxyethyl)piperazin-1-yl]-3,4-dihydronaphthalen-1(2H)-one
2.5.1.7 0.02256
-
-
Escherichia coli 6,7-dimethoxy-2-[4-(2-phenylethyl)piperazin-1-yl]-3,4-dihydronaphthalen-1(2H)-one
2.5.1.7 0.029
-
-
Staphylococcus aureus 6,7-dimethoxy-2-[4-(2-phenylethyl)piperazin-1-yl]-3,4-dihydronaphthalen-1(2H)-one