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Literature summary extracted from

  • Bonnac, L.; Gao, G.Y.; Chen, L.; Felczak, K.; Bennett, E.M.; Xu, H.; Kim, T.; Liu, N.; Oh, H.; Tonge, P.J.; Pankiewicz, K.W.
    Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis (2007), Bioorg. Med. Chem. Lett., 17, 4588-4591.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 4-phenoxybenzamide adenine dinucleotide NAD analogue which mimics isoniazid-NAD adduct Mycobacterium tuberculosis
1.3.1.9 5-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-phenoxybenzamide 25% inhibition at 0.7 mM Mycobacterium tuberculosis
1.3.1.9 [5-(3-carbamoyl-4-phenoxyphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate 12% inhibition at 0.1 mM Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Mycobacterium tuberculosis P9WGR1
-
-
1.3.1.9 Mycobacterium tuberculosis H37Rv P9WGR1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 acyl-[acyl-carrier protein] + NAD+
-
 Mycobacterium tuberculosis trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?
1.3.1.9 acyl-[acyl-carrier protein] + NAD+
-
 Mycobacterium tuberculosis H37Rv trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 InhA
-
 Mycobacterium tuberculosis
1.3.1.9 NAD-dependent enoyl-ACP reductase
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 NAD+
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.9 0.027
-
-
 Mycobacterium tuberculosis 4-phenoxybenzamide adenine dinucleotide