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Literature summary extracted from

  • Jiang, Y.L.; Chung, S.; Krosky, D.J.; Stivers, J.T.
    Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2 (2006), Bioorg. Med. Chem., 14, 5666-5672.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.23 additional information enzyme inhibitor development by high-throughput screening of triskelion libraries, a uracil-aldehyde ligand is covalently tethered to one position of a trivalent alkyloxyamine linker via an oxime linkage, and then the vacant linker positions are derivatized with a library of aldehydes, screening of triskelion oximes for inhibitory potency, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Homo sapiens the enzyme is one of the primary enzymes that prevent the incorporation and accumulation of deoxyuridine in genomic DNA, and is essential for viability dUMP + diphosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Homo sapiens
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUTP + H2O
-
 Homo sapiens dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O the enzyme is one of the primary enzymes that prevent the incorporation and accumulation of deoxyuridine in genomic DNA, and is essential for viability Homo sapiens dUMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.23 deoxyuridine triphosphate nucleotidohydrolase
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 Homo sapiens
3.6.1.23 dUTPase
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 Homo sapiens