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Literature summary extracted from

  • Perez, J.M.; Pradenas, G.A.; Navarro, C.A.; Henriquez, D.R.; Pichuantes, S.E.; Vasquez, C.C.
    Geobacillus stearothermophilus LV cadA gene mediates resistance to cadmium, lead and zinc in zntA mutants of Salmonella enterica serovar Typhimurium (2006), Biol. Res., 39, 661-668.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.2.2.12 the PCR-amplified cadA gene from Geobacillus stearothermophilus is cloned into the expression vector pBAD-TOPO Geobacillus stearothermophilus
7.2.2.21 expression of gene in Salmonella enterica serovar Typhimurium yields a cadmium hypersensitive phenotype, when a zntA-knockout mutant of Salmonella enterica (cadmium senitive) is used cadmium sensitivity is reverted Geobacillus stearothermophilus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.12 membrane
-
 Salmonella enterica subsp. enterica serovar Typhimurium 16020
-
7.2.2.12 membrane
-
 Geobacillus stearothermophilus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.12 ATP + H2O + Cd2+/in Salmonella enterica subsp. enterica serovar Typhimurium
-
 ADP + phosphate + Cd2+/out
-
 ?
7.2.2.12 ATP + H2O + Cd2+/in Geobacillus stearothermophilus
-
 ADP + phosphate + Cd2+/out
-
 ?
7.2.2.12 ATP + H2O + Pb2+/in Salmonella enterica subsp. enterica serovar Typhimurium
-
 ADP + phosphate + Pb2+/out
-
 ?
7.2.2.12 ATP + H2O + Pb2+/in Geobacillus stearothermophilus
-
 ADP + phosphate + Pb2+/out
-
 ?
7.2.2.12 ATP + H2O + Zn2+/in Salmonella enterica subsp. enterica serovar Typhimurium
-
 ADP + phosphate + Zn2+/out
-
 ?
7.2.2.12 ATP + H2O + Zn2+/in Geobacillus stearothermophilus
-
 ADP + phosphate + Zn2+/out
-
 ?
7.2.2.21 ATP + H2O + Cd2+/in Geobacillus stearothermophilus active transport of Cd2+ out of the cell to maintain metal homeostasis ADP + phosphate + Cd2+/out
-
 ?
7.2.2.21 ATP + H2O + Cd2+/in Salmonella enterica active transport of Cd2+ out of the cell to maintain metal homeostasis ADP + phosphate + Cd2+/out
-
 ?
7.2.2.21 ATP + H2O + Cd2+/in Geobacillus stearothermophilus LV active transport of Cd2+ out of the cell to maintain metal homeostasis ADP + phosphate + Cd2+/out
-
 ?
7.2.2.21 additional information Geobacillus stearothermophilus involved in Cd2+, Pb2+, and Zn2+ resistance ?
-
 ?
7.2.2.21 additional information Salmonella enterica involved in Cd2+, Pb2+, and Zn2+ resistance, not involved in Hg2+ resistance ?
-
 ?
7.2.2.21 additional information Geobacillus stearothermophilus LV involved in Cd2+, Pb2+, and Zn2+ resistance ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.12 Geobacillus stearothermophilus
-
 Salmonella enterica serovar typhimurium cells expressing the cadA gene of Geobacillus stearothermophilus
-
7.2.2.12 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
7.2.2.21 Geobacillus stearothermophilus Q93GJ9
-
-
7.2.2.21 Geobacillus stearothermophilus LV Q93GJ9
-
-
7.2.2.21 Salmonella enterica Q8ZLE5 serovar Typhimurium, use of wild type and a cadmium senitive zntA-knockout mutant, expression of cadA gene from Geobacillus stearothermophilus LV in wild type yields a cadmium hypersensitive phenotype, when the zntA-knockout mutant is used cadmium sensitivity is reverted
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.12 ATP + H2O + Cd2+/in
-
 Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + Cd2+/out
-
 ?
7.2.2.12 ATP + H2O + Cd2+/in
-
 Geobacillus stearothermophilus ADP + phosphate + Cd2+/out
-
 ?
7.2.2.12 ATP + H2O + Pb2+/in
-
 Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + Pb2+/out
-
 ?
7.2.2.12 ATP + H2O + Pb2+/in
-
 Geobacillus stearothermophilus ADP + phosphate + Pb2+/out
-
 ?
7.2.2.12 ATP + H2O + Zn2+/in
-
 Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + Zn2+/out
-
 ?
7.2.2.12 ATP + H2O + Zn2+/in
-
 Geobacillus stearothermophilus ADP + phosphate + Zn2+/out
-
 ?
7.2.2.21 ATP + H2O + Cd2+/in active transport of Cd2+ out of the cell to maintain metal homeostasis Geobacillus stearothermophilus ADP + phosphate + Cd2+/out
-
 ?
7.2.2.21 ATP + H2O + Cd2+/in active transport of Cd2+ out of the cell to maintain metal homeostasis Salmonella enterica ADP + phosphate + Cd2+/out
-
 ?
7.2.2.21 ATP + H2O + Cd2+/in active transport of Cd2+ out of the cell to maintain metal homeostasis Geobacillus stearothermophilus LV ADP + phosphate + Cd2+/out
-
 ?
7.2.2.21 additional information involved in Cd2+, Pb2+, and Zn2+ resistance Geobacillus stearothermophilus ?
-
 ?
7.2.2.21 additional information involved in Cd2+, Pb2+, and Zn2+ resistance, not involved in Hg2+ resistance Salmonella enterica ?
-
 ?
7.2.2.21 additional information involved in Cd2+, Pb2+, and Zn2+ resistance Geobacillus stearothermophilus LV ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.12 CadA
-
 Salmonella enterica subsp. enterica serovar Typhimurium
7.2.2.12 CadA
-
 Geobacillus stearothermophilus
7.2.2.12 P-type ATPase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
7.2.2.12 P-type ATPase
-
 Geobacillus stearothermophilus
7.2.2.12 ZntA
-
 Salmonella enterica subsp. enterica serovar Typhimurium
7.2.2.12 ZntA
-
 Geobacillus stearothermophilus
7.2.2.21 CadA
-
 Geobacillus stearothermophilus
7.2.2.21 ORF STM3576 gene product
-
 Salmonella enterica
7.2.2.21 ZntA
-
 Salmonella enterica
7.2.2.21 zntA gene product
-
 Salmonella enterica