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Literature summary extracted from

  • Hu, Y.; Urig, S.; Koncarevic, S.; Wu, X.; Fischer, M.; Rahlfs, S.; Mersch-Sundermann, V.; Becker, K.
    Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents (2007), Biol. Chem., 388, 1069-1081.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 allyl isothiocyanate
-
 Homo sapiens
1.8.1.7 Benzyl isothiocyanate
-
 Homo sapiens
1.8.1.7 phenethyl isothiocyanate
-
 Homo sapiens
1.8.1.7 sulforaphane
-
 Homo sapiens
1.8.1.9 allyl isothiocyanate 0.0205 mM, 50% inhibition after 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate Homo sapiens
1.8.1.9 Benzyl isothiocyanate 0.0033 mM, 50% inhibition after 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate Homo sapiens
1.8.1.9 diallyl disulfide 0.38 mM, 50% inhibition after 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate Homo sapiens
1.8.1.9 phenethyl isothiocyanate 0.075 mM, 50% inhibition after 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate Homo sapiens
1.8.1.9 sulforaphane 0.04 mM, 50% inhibition after 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens P00390
-
-
1.8.1.9 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 placenta
-
 Homo sapiens
-
1.8.1.9 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 GSSG + NADPH + H+
-
 Homo sapiens glutathione + NADP+
-
 ?
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
 Homo sapiens 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Homo sapiens thioredoxin + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
 Homo sapiens
1.8.1.7 GR
-
 Homo sapiens
1.8.1.9 TrxR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.7 0.029
-
 25°C, 30 min preincubation Homo sapiens Benzyl isothiocyanate
1.8.1.7 0.045
-
 25°C, 30 min preincubation Homo sapiens sulforaphane
1.8.1.7 0.05
-
 25°C, 30 min preincubation Homo sapiens phenethyl isothiocyanate
1.8.1.7 0.1
-
 25°C, 30 min preincubation Homo sapiens allyl isothiocyanate
1.8.1.9 0.0033
-
 25°C, 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate Homo sapiens Benzyl isothiocyanate
1.8.1.9 0.0205
-
 25°C, 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate Homo sapiens allyl isothiocyanate
1.8.1.9 0.04
-
 25°C, 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate Homo sapiens sulforaphane
1.8.1.9 0.075
-
 25°C, 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate Homo sapiens phenethyl isothiocyanate
1.8.1.9 0.38
-
 25°C, 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate Homo sapiens diallyl disulfide