Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kajimoto, S.; Horie, M.; Manabe, H.; Masuda, Y.; Shibayama-Imazu, T.; Nakajo, S.; Gong, X.F.; Obama, T.; Itabe, H.; Nakaya, K.
    A tyrosine kinase inhibitor, beta-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity (2008), Biochim. Biophys. Acta, 1782, 41-50.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.6.1.23 additional information increase in the expression of dUTPase in human lung and ovarian tumor cell lines is known to result in resistance to 5-fluorouracil Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.23 beta-hydroxyisovalerylshikonin an ATP-noncompetitive inhibitor of protein tyrosine kinases, induces apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity, acts synergistically with 5-fluorouracil, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.23 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.23 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Homo sapiens enzyme inhibition is involved in apoptosis in cancer cells and decreases the sensitivity of cells for 5-fluorouracil, overview dUMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Homo sapiens P33316
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.6.1.23 phosphoprotein nuclear dUTPase is phosphorylated by the phosphorylated cyclin-cdc2 complex Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.23 DMS-114 cell
-
 Homo sapiens
-
3.6.1.23 lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUTP + H2O
-
 Homo sapiens dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O enzyme inhibition is involved in apoptosis in cancer cells and decreases the sensitivity of cells for 5-fluorouracil, overview Homo sapiens dUMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.23 dUTP nucleotidohydrolase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.1.23 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.23 7.5
-
 assay at Homo sapiens