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Literature summary extracted from
- Electrochemical reduction of sterol-14alpha-demethylase from Mycobacterium tuberculosis (CYP51b1) (2007), Biochemistry (Moscow), 72, 658-663.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.14.14.154 | additional information | direct electron transfer is measured between CYP51 and graphite screen-printed electrodes modified with gold nanoparticles and with the membrane-like synthetic surfactant didodecyl dimethylammonium bromide, determination of the formal potential of the Fe3+/Fe2+ pair, detailed overview, lanosterol addition to the oxygenated solution causes a concentration-dependent increase in the reduction current in voltammetric and amperometric experiments | Mycobacterium tuberculosis |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.154 | ketoconazole | - |
Mycobacterium tuberculosis |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.154 | Fe2+ | a cytochrome P450 enzyme | Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.154 | lanosterol + O2 + NADPH + H+ | Mycobacterium tuberculosis | - |
4,4-dimethyl-5alpha-cholesta-8,14,24-triene-3beta-ol + formate + NADP+ + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.154 | Mycobacterium tuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.154 | lanosterol + O2 + NADPH + H+ | - |
Mycobacterium tuberculosis | 4,4-dimethyl-5alpha-cholesta-8,14,24-triene-3beta-ol + formate + NADP+ + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.154 | CYP51 | - |
Mycobacterium tuberculosis |
| 1.14.14.154 | CYP51b1 | - |
Mycobacterium tuberculosis |
| 1.14.14.154 | sterol-14alpha-demethylase | - |
Mycobacterium tuberculosis |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.154 | cytochrome P450 | a cytochrome P450 enzyme | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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