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Literature summary extracted from

  • Xu, H.; West, A.H.; Cook, P.F.
    Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae (2007), Biochemistry, 46, 7625-7636.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.7 2',3'-cyclic NADP
-
 Saccharomyces cerevisiae
1.5.1.7 2',3'-cyclic NADP+
-
 Saccharomyces cerevisiae
1.5.1.7 adenosine
-
 Saccharomyces cerevisiae
1.5.1.7 adipate
-
 Saccharomyces cerevisiae
1.5.1.7 ADP
-
 Saccharomyces cerevisiae
1.5.1.7 ADP-ribose
-
 Saccharomyces cerevisiae
1.5.1.7 alpha-ketoadipate
-
 Saccharomyces cerevisiae
1.5.1.7 alpha-ketoglutarate
-
 Saccharomyces cerevisiae
1.5.1.7 alpha-ketoisovalerate
-
 Saccharomyces cerevisiae
1.5.1.7 alpha-ketomalonate
-
 Saccharomyces cerevisiae
1.5.1.7 alpha-ketopimelate
-
 Saccharomyces cerevisiae
1.5.1.7 AMP
-
 Saccharomyces cerevisiae
1.5.1.7 D-Lysine
-
 Saccharomyces cerevisiae
1.5.1.7 Glutarate
-
 Saccharomyces cerevisiae
1.5.1.7 L-arginine
-
 Saccharomyces cerevisiae
1.5.1.7 L-glutamine
-
 Saccharomyces cerevisiae
1.5.1.7 L-isoleucine
-
 Saccharomyces cerevisiae
1.5.1.7 L-leucine dead-end inhibition by L-leucine is uncompetitive versus NADPH Saccharomyces cerevisiae
1.5.1.7 L-lysine
-
 Saccharomyces cerevisiae
1.5.1.7 L-methionine
-
 Saccharomyces cerevisiae
1.5.1.7 L-norvaline
-
 Saccharomyces cerevisiae
1.5.1.7 L-ornithine
-
 Saccharomyces cerevisiae
1.5.1.7 L-valine
-
 Saccharomyces cerevisiae
1.5.1.7 malonate
-
 Saccharomyces cerevisiae
1.5.1.7 additional information not inhibited by L-asparagine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 NAD+
-
 Saccharomyces cerevisiae
1.5.1.7 NADH
-
 Saccharomyces cerevisiae
1.5.1.7 NADP+ NADP+ is competitive versus NADPH when NADPH serves as the coenzyme Saccharomyces cerevisiae
1.5.1.7 NMN
-
 Saccharomyces cerevisiae
1.5.1.7 oxalate
-
 Saccharomyces cerevisiae
1.5.1.7 oxaloacetate
-
 Saccharomyces cerevisiae
1.5.1.7 oxalylglycine
-
 Saccharomyces cerevisiae
1.5.1.7 pyridine 2,3-dicarboxylate
-
 Saccharomyces cerevisiae
1.5.1.7 Pyridine 2,4-dicarboxylate
-
 Saccharomyces cerevisiae
1.5.1.7 succinate
-
 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.7 0.11
-
 2-oxoglutarate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 4.1
-
 pyruvate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 5.3
-
 alpha-ketoadipate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 6.4
-
 glyoxylate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 24
-
 alpha-ketomalonate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 94
-
 alpha-ketovalerate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 153
-
 alpha-Ketobutyrate at pH 7.0 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.7 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.7 L-lysine + alpha-ketoadipate + NADH
-
 Saccharomyces cerevisiae ?
-
 ?
1.5.1.7 L-lysine + alpha-ketobutyrate + NADH
-
 Saccharomyces cerevisiae ?
-
 ?
1.5.1.7 L-lysine + alpha-ketomalonate + NADH
-
 Saccharomyces cerevisiae ?
-
 ?
1.5.1.7 L-lysine + alpha-ketovalerate + NADH
-
 Saccharomyces cerevisiae ?
-
 ?
1.5.1.7 L-lysine + glyoxylate + NADH
-
 Saccharomyces cerevisiae ?
-
 ?
1.5.1.7 L-lysine + pyruvate + NADH
-
 Saccharomyces cerevisiae ?
-
 ?
1.5.1.7 additional information 3-acetylpyridine adenine dinucleotide, 3-pyridinealdehyde adenine dinucleotide, and thionicotinamide adenine dinucleotide can serve as a substrate in the oxidative deamination reaction, as can glyoxylate, pyruvate, alpha-ketobutyrate, alpha-ketovalerate, alpha-ketomalonate, and alpha-ketoadipate in the reverse reaction Saccharomyces cerevisiae ?
-
 ?
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O the enzyme is specific for L-lysine Saccharomyces cerevisiae L-lysine + 2-oxoglutarate + NADH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.5.1.7 N6-(glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)
-
 Saccharomyces cerevisiae
1.5.1.7 SDH
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.7 NAD+
-
 Saccharomyces cerevisiae
1.5.1.7 NADH
-
 Saccharomyces cerevisiae
1.5.1.7 NADPH NADPH can substitute for NADH Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.7 0.018
-
 NADH at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 0.055
-
 AMP at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 0.093
-
 ADP at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 0.1
-
 oxalylglycine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 0.125
-
 L-leucine at pH 6.0 Saccharomyces cerevisiae
1.5.1.7 0.29
-
 ADP-ribose at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 0.42
-
 adenosine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 0.6
-
 alpha-ketoglutarate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 1
-
 Glutarate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 1.1
-
 L-lysine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 1.1
-
 Pyridine 2,4-dicarboxylate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 1.13
-
 L-norvaline at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 1.2
-
 NADP at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 1.5
-
 2',3'-cyclic NADP at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 1.56
-
 NAD+ at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 3.12
-
 L-methionine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 3.5
-
 NADP+ at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 5
-
 L-ornithine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 5.3
-
 alpha-ketoadipate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 5.5
-
 D-Lysine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 5.6
-
 L-leucine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 6.4
-
 oxaloacetate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 7.2
-
 NMN at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 16
-
 L-glutamine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 16.4
-
 L-arginine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 18
-
 alpha-ketopimelate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 18.3
-
 pyridine 2,3-dicarboxylate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 21
-
 succinate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 22
-
 L-isoleucine at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 24
-
 malonate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 24
-
 alpha-ketomalonate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 36
-
 oxalate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 36
-
 alpha-ketoisovalerate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 50
-
 adipate at pH 7.0 Saccharomyces cerevisiae
1.5.1.7 140
-
 L-valine at pH 7.0 Saccharomyces cerevisiae