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Literature summary extracted from

  • Ho, K.K.; Mukhopadhyay, A.; Li, Y.F.; Mukhopadhyay, S.; Weiner, H.
    A point mutation produced a class 3 aldehyde dehydrogenase with increased protective ability against the killing effect of cyclophosphamide (2008), Biochem. Pharmacol., 76, 690-696.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.5 expressed in Escherichia coli BL21 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.5 T186S the mutant has increased activity against aldehyde and decreased activity against smaller substrates like benzaldehyde compared to the native enzyme and cells transformed with the point mutant are better protected against the killing effect of cyclophosphamides Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.5 Homo sapiens P30838
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.5 nickel affinity column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.5 stomach
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.5 acetaldehyde + NADP+ + H2O
-
 Homo sapiens acetate + NADPH + H+
-
 ?
1.2.1.5 mafosfamide + NADP+ + H2O
-
 Homo sapiens ?
-
 ?
1.2.1.5 p-hydroxybenzaldehyde + NADP+ + H2O
-
 Homo sapiens p-hydroxybenzoic acid + NADPH + H+
-
 ?
1.2.1.5 p-nitrobenzaldehyde + NADP+ + H2O
-
 Homo sapiens p-nitrobenzoate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.5 ALDH3
-
 Homo sapiens
1.2.1.5 class 3 aldehyde dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.5 NADP+
-
 Homo sapiens