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Literature summary extracted from

  • Liekens, S.; Bronckaers, A.; Perez-Perez, M.J.; Balzarini, J.
    Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy (2007), Biochem. Pharmacol., 74, 1555-1567.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.4 cyclophosphamide induces thymidine phosphorylase expression Homo sapiens
2.4.2.4 docetaxel induces thymidine phosphorylase expression Homo sapiens
2.4.2.4 interferon alpha causes a rapid and transient increase of thymidine phosphorylase expression Homo sapiens
2.4.2.4 interferon beta causes a rapid and transient increase of thymidine phosphorylase expression Homo sapiens
2.4.2.4 interferon gamma causes a rapid and transient increase of thymidine phosphorylase expression Homo sapiens
2.4.2.4 interleukin-1beta the expression of tyhmidine phosphorylase mRNA is significantly increased by stimulation with interleukin-1beta Homo sapiens
2.4.2.4 mitomycin C induces thymidine phosphorylase expression Homo sapiens
2.4.2.4 additional information the enzymatic activity of thymidine phosphorylase is required for the activation of 5-fluorouracil prodrugs, the enzyme induces the expression of several matrix metalloproteinases, increases the levels of hypoxia-inducible factor 1alpha during in vitro hypoxia Homo sapiens
2.4.2.4 paclitaxel induces thymidine phosphorylase expression Homo sapiens
2.4.2.4 Tumor necrosis factor alpha causes a rapid and transient increase of thymidine phosphorylase expression Homo sapiens

Application

EC Number Application Comment Organism
2.4.2.4 medicine thymidine phosphorylase expression correlates well with tumor grade, metastasis and shorter patient survival in colorectal, pancreatic, renal, ovarian, cervical, bladder and non-small cell lung cancer, loss of function mutants of thymidine phosphorylase case the disease mitochondrial neurogastrointestinal encephalomyopathy Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.2.4
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.4 L148R mutant devoid of enzymatic activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 5'-O-tritylinosine
-
 Homo sapiens
2.4.2.4 5-chloro-6-[1-(2-iminopyrrolidinyl)methyl]uracil hydrochloride
-
 Homo sapiens
2.4.2.4 6-amino-5-bromouracil
-
 Homo sapiens
2.4.2.4 6-amino-5-chlorouracil
-
 Homo sapiens
2.4.2.4 6-aminothymine
-
 Homo sapiens
2.4.2.4 aurothioglucose the expression of tyhmidine phosphorylase mRNA is significantly decreased by stimulation with aurothioglucose Homo sapiens
2.4.2.4 dexamethasone the expression of tyhmidine phosphorylase mRNA is significantly decreased by stimulation with dexamethasone Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.4 A-431 cell
-
 Homo sapiens
-
2.4.2.4 colonic cancer cell
-
 Homo sapiens
-
2.4.2.4 gastrointestinal tract high expression Homo sapiens
-
2.4.2.4 HT-29 cell
-
 Homo sapiens
-
2.4.2.4 KK-47 cell
-
 Homo sapiens
-
2.4.2.4 MKN-74 cell
-
 Homo sapiens
-
2.4.2.4 prostate cancer cell
-
 Homo sapiens
-
2.4.2.4 RT-112 cell
-
 Homo sapiens
-
2.4.2.4 THP-1 cell
-
 Homo sapiens
-
2.4.2.4 U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 5'-deoxy-5-fluorouridine + phosphate
-
 Homo sapiens 5-fluorouracil + 5-deoxyribose-1-phosphate
-
 ?
2.4.2.4 5-fluoro-2'-deoxyuridine + phosphate
-
 Homo sapiens 5-fluorouracil + 2-deoxyribose-1-phosphate
-
 r
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.4 dimer x-ray crystallography Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.2.4 gliostatin
-
 Homo sapiens
2.4.2.4 PD-ECGF
-
 Homo sapiens
2.4.2.4 platelet-derived endothelial cell growth factor
-
 Homo sapiens