Literature summary extracted from

Ikeda, R.; Tajitsu, Y.; Iwashita, K.; Che, X.F.; Yoshida, K.; Ushiyama, M.; Furukawa, T.; Komatsu, M.; Yamaguchi, T.; Shibayama, Y.; Yamamoto, M.; Zhao, H.Y.; Arima, J.; Takeda, Y.; Akiyama, S.; Yamada, K.
Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3 (2008), Biochem. Biophys. Res. Commun., 370, 220-224.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.4.2.4	expressed in Jurkat cells	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.4.2.4	additional information	thymidine phosphorylase and its degradation product 2-deoxy-D-ribose suppress hypoxia-induced apoptosis, the upregulation of hypoxia-inducible factor 1alpha and the proapoptotic factor, BNIP3, and caspase 3 activation induced by hypoxia	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.2.4	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.2.4	thymidine + phosphate	-	Homo sapiens	thymine + 2-deoxy-D-ribose 1-phosphate	-	r

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Release 2023.1 (January 2023)